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'Peptides' in keywords Facet   section ZfN Section C  [X]
Facet   Publication Year 1997  [X]
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1997[X]
1Author    Amelia Thereza, Roberto Soares3, Ricardo Dias Lins3, RichardG. Longo3, Ricardo Arrattb, Ferreira3Requires cookie*
 Title    Plural Origins of Molecular Homochirality in Our Biota Part II. The Relative Stabilities of Homochiral and Mixed Oligoribotides and Peptides  
 Abstract    By computer simulations -molecular mechanics and molecular dynamics with the amber force field (Weiner et al., (1986), J. Comp. Chem. 7, 2 3 0 -2 5 2) -we have determined the stabilities of oligoribotide strands built with d -and L-riboses, and of peptide chains with d -and L-amino acid residues. In particular, complementary double-chains of oligoribotides were studied, since they are an important feature of the growing mechanism o f modern nucleic acids. Peptide chains on the other hand, grow without need of a template. We found that mixed oligoribotides are less stable than homochiral ones, and that this chiral effect is less noticeable in peptide chains. The results support the interpretation that L-riboses act as termi­ nators to the template-assisted growth of oligo-r-GD (enantiomeric cross-inhibition; Joyce et al., (1987), Proc. Natl. Acad. Sei. U S A 84, 4 398-4402). Based on this effect, a chemical pathway is proposed which could, under assumed prebiotic conditions, bypass the hindrance of homochiral growth. 
  Reference    Z. Naturforsch. 52c, 89 (1997); received July 10/September 4 1996 
  Published    1997 
  Keywords    Chirality, Peptides, Oligoribotides, Computer Simulations 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0089.pdf 
 Identifier    ZNC-1997-52c-0089 
 Volume    52