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'Peptides' in keywords Facet   section ZfN Section C  [X]
Facet   Publication Year 1986  [X]
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1986[X]
1Author    Karl Folkers, Cyril Bowers, Pui-FunL. Tang, Minoru Kobota, Xiao Shao-Bo, Wolf­ Gang Bender, Liu Yin-ZengRequires cookie*
 Title    Relative Potencies of Antagonists of the Luteinizing Hormone Releasing Hormone with Lys8 and Arg8 and Substitutions in Positions 3 ,5 ,6 ,7 and 8d-Ala10] — N H 2 and [N -A c—D-2  
 Abstract    Antagonists of the luteinizing hormone releasing hormone (L H R H) of increased potency is a goal for control of ovulation. In the design and synthesis of 26 decapeptides, emphasis was given to analogs with Lys8 and Arg8 and with various substitutions in positions 3, 5, 6, 7 and 8. Two antagonists, [N — A c—D-2-Nal]-N H 2 showed 80-85% antiovulatory activity (A O A) at 0.25 (ig in the rat. The latter antagonist showed 60% A O A at 0.125 ^.g. O f four pairs of analogs with Arg8 and Lys8, respectively, two pairs favored Lys8 over Arg8 for potency. One pair showed negligible difference and another pair favored Arg8 over Lys8. There is specificity of substitution for potency. In other antagonists, d -3-Pal3, Tyr5 or Phe5, D-Arg6 and Leu7 or Nie7 or Val7 and Arg8 were variously effective substitutions for increase of potency and reduction of histamine release. 
  Reference    Z. Naturforsch. 41c, 1087—1091 (1986); received June 10 1986 
  Published    1986 
  Keywords    Luteinizing Hormone Releasing Hormone, Ovulation, Peptide, Antagonist, Histamine Release 
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 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-1087.pdf 
 Identifier    ZNC-1986-41c-1087 
 Volume    41 
2Author    H.Peter Matthiessen, H.Rainer MaurerRequires cookie*
 Title    Low Molecular Mass Inhibitors from Calf Thymus Selective for T-Lymphocyte Proliferation  
 Abstract    Endogenous factors preferentially inhibiting T-lympho-cyte proliferation were prepared from the acetone precipi­ tate of a 60% ethanol extract from calf thymus and their biochemical properties examined. By ultrafiltration the strongest lymphocyte-selective inhibition was found in the molecular mass range between 1 and 5 kDa. Fast protein liquid chromatography (FPLC) of this fraction on an anion exchange column eluted the lymphocyte inhibitors at 205—265 mM ammonium acetate. Staining procedures following IEF and TLC suggested, that the inhibitors may not be glycoconjugates or amines but small weakly acidic peptides (< 3 kDa). 
  Reference    Z. Naturforsch. 41c, 1131 (1986); received November 11 1985/July 18 1986 
  Published    1986 
  Keywords    Lymphocyte Proliferation Inhibitors, Calf Thymus, Peptides, Chalone, Colony Formation 
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 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-1131_n.pdf 
 Identifier    ZNC-1986-41c-1131_n 
 Volume    41