| 1 | Author | H. Hauer, H.-D Lüdemann, R. Jaenicke | Requires cookie* |
| Title | Free Activation Energies and Activation Volumes for the Amide Rotation in Some Peptides Studied by High Pressure 'H-High Resolution NMR  | ||
| Abstract | From the pressure dependence o f !H high resolution N M R spectra o f two dipeptides (glycylsarcosine and N-acetyl-L-proline-NH-methylamide in the range 0.1 MPa <.p< . 150 MPa the activation volumes A V* for the am ide rotation are derived. This conform ational transition is characterized for glycylsarcosine by A V* = 4 ± 1 cm3 • m ol-1 and for. the proline derivative by AV* = 1 .5 ± 1 cm3 • m ol-1. From the given results the m axim um contribution o f proline cis ^ trans isomerisation to the pressure dependence o f the rate o f reactivation of proteins can be estimated to ~ — 30% per M Pa and proline present. | ||
| Reference | Z. Naturforsch. 37c, 51—56 (1982); received Septem ber 221981 | ||
| Published | 1982 | ||
| Keywords | Activation Volume, High Pressure, NM R, Peptides, Proline-Isom erization | ||
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