Go toArchive
Browse byFacets
Bookbag ( 0 )
'Peptide' in keywords
Results  16 Items
Sorted by   
Publication Year
1999 (2)
1997 (1)
1993 (1)
1987 (2)
1986 (2)
1985 (1)
1983 (1)
1982 (2)
1981 (1)
1977 (1)
1Author    W.Requires cookie*
 Title    Circulardichroismusuntersuchungen des Thyreotropin-Releasinghormons (TRH) Circular Dichroism Investigations of TRH  
 Abstract    o l f g a n g V o e l t e r , K a r l Z e c h , P e t e r G ö b e l , O s k a r O s t e r u n d A n t o n io A t t a n a s io Im Zusammenhang mit Untersuchungen zur Struktur13 und Wirkungsweise4 der kürzlich aufge­ klärten5-6 Hypothalamus-Releasinghormone haben wir Circulardichroismus(CD)-Spektren des Thyreo­ tropin-Releasinghormons (TRH) vermessen, da mit der Methode des CD konformative und konfi­ gurative Änderungen optisch aktiver Moleküle nachweisbar sind. TRH wird durch Kuppeln der Aminosäurederi­ vate Benzyloxycarbonyl-(4.4'-dimethoxybenzhy-dryl)-L-glutamin, L-Histidin-methylester und l -Prolinamid mit N.N'-Dicyclohexylcarbodiimid dar­ gestellt3. Die Primärstruktur von TRH ist Pyr-His-Pro-NH2. 
  Reference    (Z. Naturforsch. 30b, 142—143 [1975]; eingegangen am 15. September 1973) 
  Published    1975 
  Keywords    Circular Dichroism, Releasing Hormones, Peptides 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/30/ZNB-1975-30b-0142_n.pdf 
 Identifier    ZNB-1975-30b-0142_n 
 Volume    30 
2Author    Dorothee Petz, Friedhelm SchneiderRequires cookie*
 Title    Kinetic Analysis of the Catalytic Properties of Peptides in Ester Hydrolysis  
 Abstract    The catalytic properties of peptides containing histidine, cysteine and aspartic acid in ester hydrolysis were studied. Saturation kinetics were found for the reaction of p-nitrophenyl acetate (NPA) with Z-His-Ala-Asp-Gly-Cys-NH2 and Z-His-Ala-Gly-Gly-Cys-NH2 . The Brönsted equation for the hydrolysis of Zer«-butyloxycarbonyl-L-alanine-p-nitrophenylester (Boc-Ala-ONp) catalyzed by simple imidazole and SH-compounds was determined. The catalytic behaviour of the peptides in ester hydrolysis could not be described by the Brönsted equations for imidazole or thiole catalyzed hydrolysis of NPA and Boc-Ala-ONp. The pH dependence of the rate constants of the catalyzed ester hydrolysis gave no linear plots in 1 Jk versus H+ diagrams. 
  Reference    (Z. Naturforsch. 31c, 675 [1976]; received September 20 1976) 
  Published    1976 
  Keywords    Kinetic Properties, Peptides, Ester Hydrolysis 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/31/ZNC-1976-31c-0675.pdf 
 Identifier    ZNC-1976-31c-0675 
 Volume    31 
3Author    Amelia Thereza, Roberto Soares3, Ricardo Dias Lins3, RichardG. Longo3, Ricardo Arrattb, Ferreira3Requires cookie*
 Title    Plural Origins of Molecular Homochirality in Our Biota Part II. The Relative Stabilities of Homochiral and Mixed Oligoribotides and Peptides  
 Abstract    By computer simulations -molecular mechanics and molecular dynamics with the amber force field (Weiner et al., (1986), J. Comp. Chem. 7, 2 3 0 -2 5 2) -we have determined the stabilities of oligoribotide strands built with d -and L-riboses, and of peptide chains with d -and L-amino acid residues. In particular, complementary double-chains of oligoribotides were studied, since they are an important feature of the growing mechanism o f modern nucleic acids. Peptide chains on the other hand, grow without need of a template. We found that mixed oligoribotides are less stable than homochiral ones, and that this chiral effect is less noticeable in peptide chains. The results support the interpretation that L-riboses act as termi­ nators to the template-assisted growth of oligo-r-GD (enantiomeric cross-inhibition; Joyce et al., (1987), Proc. Natl. Acad. Sei. U S A 84, 4 398-4402). Based on this effect, a chemical pathway is proposed which could, under assumed prebiotic conditions, bypass the hindrance of homochiral growth. 
  Reference    Z. Naturforsch. 52c, 89 (1997); received July 10/September 4 1996 
  Published    1997 
  Keywords    Chirality, Peptides, Oligoribotides, Computer Simulations 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0089.pdf 
 Identifier    ZNC-1997-52c-0089 
 Volume    52 
4Author    Kosaku Nöda, Erhard GrossRequires cookie*
 Title    Solid-Phase Synthesis of Peptides via a,ß-Unsaturated Amino Acids. Incorporation of the Amide Gronp in encZo-Positions  
 Abstract    Dehydroalanine is introduced as pseudo-protecting group for the to-amide function of Asn and Gin in solid-phase peptide synthesis. Using Boc-X(Dha-NHMe)-OH (X = Asp or Glu), the model peptides, L-Leu-L-Asn-Gly-NH2 and L-Leu-Lr-Gln-Gly-NH2, were synthesized. 
  Reference    Z. Naturforsch. 36b, 1345—1347 (1981); received July 15 1981 
  Published    1981 
  Keywords    Amide Group, Dehydroalanine, Peptide, Solid-Phase Synthesis 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/36/ZNB-1981-36b-1345.pdf 
 Identifier    ZNB-1981-36b-1345 
 Volume    36 
5Author    Karl Folkers, CyrilY. Bowers+, WilsonB. Lutz, Klaus Friebel, Teresa Kubiak, Bernhard Schircks, Georg RampoldRequires cookie*
 Title    Synthesis and Bioassay of Antagonists of the Luteinizing Hormone Releasing Hormone Having the Azagly 10 Moiety  
 Abstract    Seven new analogs of the luteinizing hormone releasing hormone (LHRH), having an Azagly 10 moiety, and three corresponding Gly 10 -analogs were synthesized for bioassay and comparison of inhibitory potencies. This study was toward a possible advantage of the Azagly 10 moiety to minimize C-terminal degradation, in vivo. Of the three procedures which were studied to achieve Azagly 10 -peptides, the reaction of cyanate ion with hydrazides was the most favorable. Variations of substitution in position 1 were also studied. The data from the antiovulatory assay showed that an Azagly 10 moiety may not depress activity, and may allow equal or even higher activity than the Glv 10 moiety, depending on the analog. [N-Ac-D-Thr 1 , D-p-Cl-Phe 2 , D-Trp 3 -6 , Azagly 10 ] LHRH was more inhibitory than the corresponding Gly 10 -analog. Based on pairs of analogs, the following relationships appeared: (1) N-Ac-D-Thr 1 was more effective than N-Ac-jo-Cl-Phe 1 ; (2) The L-configuration of Ala as N-Ac-Ala 1 -was more effective than the D—; (3) N-Ac-Ala 1 appeared more effective than the N-Ac-D-Thr 1 ; (4) D-Trp 6 appeared more effective than D-Phe 6 . In an ultimate clinical use of an antagonist of LHRH to block ovulation, the Azagly 10 moiety may be advantageous for limitation of enzymatic degradation. 
  Reference    Z. Naturforsch. 37b, 1075—1081 (1982); received March 23 1982 
  Published    1982 
  Keywords    Antagonist, Luteinizing Hormone Releasing Hormone, Ovulation, Peptides, Azaglycine 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-1075.pdf 
 Identifier    ZNB-1982-37b-1075 
 Volume    37 
6Author    A. Marston, E. HeckerRequires cookie*
 Title    Structure-Activity Relationships of Polyfunctional Diterpenes of the Tigliane Type, V* Preparation and Irritant Activities of Amino Acid and Peptide Esters of Phorbol  
 Abstract    The synthesis of a series of 12-O-amino acyl-and 12-0-peptidyl-13-acetate and -13,20-diacetate esters of the tetracyclic diterpene alcohol phorbol is described. These esters, which include amino acid moieties with both N-protected and free amino functions, were all tested for irritant activity on mouse ear. The highest activities were observed for esters with N-9-fluorenylmethyloxycarbonyl-protected leucine and 11-aminoundecanoic acid. 
  Reference    Z. Naturforsch. 38b, 1015—1021 (1983); received March 28 1983 
  Published    1983 
  Keywords    Amino Acids, Peptides, Phorbol Esters, Irritants, Tumour Promoters 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1015.pdf 
 Identifier    ZNB-1983-38b-1015 
 Volume    38 
7Author    Karl Folkers, CyrilY. Bowers, Yin-Zeng Liu, Xiao Shao-Bo, Hong-Ming Shieh, Chu Ji-YuRequires cookie*
 Title    Antagonists of the Luteinizing Hormone Releasing Hormone with Emphasis on Amino Acids in Position Five  
 Abstract    Seventeen analogs of the luteinizing hormone releasing hormone (LHRH) have been syn-thesized, bioassayed, and compared for antiovulatory activity (AOA) in rats. The emphasis of design was replacement of Tyr 5 of LHRH. Position 5 has not been extensively studied. [N—Ac—D-2-Nal 1 , D-pClPhe 2 , D-3-Pal 3 , D-Arg 6 , D—Ala 10 ]-LHRH was the baseline for new designs. Comparison of the AOA's of the 17 analogs with the baseline revealed the two peptides with Phe 5 and 3-Pal 5 had equivalent AOA's, and were the best of the 17, and about 45% more potent than the baseline. Analogs with pClPhe 5 , oClPhe 5 , a-MepClPhe 5 , 2-Nal 5 , Trp 5 , and His 5 were less potent than the Phe 5 -and 3-Pal 5 -analogs. Based on the Phe 5 -analog, eight other analogs were synthesized with changes in positions 1, 2, 3 and 7 and although none were better than the baseline, 5/8 showed 20—60% AOA's at 250 ng and revealed optimum positions for new designs. 
  Reference    Z. Naturforsch. 40b, 313—316 (1985); received August 20 1984 
  Published    1985 
  Keywords    Peptide, Hormone, Ovulation, Luteinizing Hormone Releasing Hormone, Antagonist 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/40/ZNB-1985-40b-0313.pdf 
 Identifier    ZNB-1985-40b-0313 
 Volume    40 
8Author    Luigi Sportelli, H. Arald Neubacher, Wolfgang LohmannRequires cookie*
 Title    N O T I Z E N On the Influence of Arom atic R esidues on the Interaction of Copper (II) w ith Small P eptides Containing Arom atic Am ino Acids: ESR and Optical Studies  
 Abstract    The complexation behaviour of C u(II) with di-and tri­ peptides containing the aromatic amino acids phenylalanine or tryptophan has been investigated at different pH-values and compared with results obtained with di-and triglycine. The results obtained by means of ESR and optical absorp­ tion spectroscopy show an influence of the two different aromatic entities on the magnetic and optical param eters. A significant decrease of the < 7||-value and, concom ittantly, an increase of the energy of the d-d transition was m easured when an aromatic entity is present in the peptide. A possible explanation for this observation is given. 
  Reference    (Z. Naturforsch. 32c, 643 [1977]; received May 4 1977) 
  Published    1977 
  Keywords    Copper (II)-Complexes, Peptides, Aromatic Amino Acids, Optical Absorption 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/32/ZNC-1977-32c-0643_n.pdf 
 Identifier    ZNC-1977-32c-0643_n 
 Volume    32 
9Author    Karl Folkers, Cyril Bowers, Pui-FunL. Tang, Minoru Kobota, Xiao Shao-Bo, Wolf­ Gang Bender, Liu Yin-ZengRequires cookie*
 Title    Relative Potencies of Antagonists of the Luteinizing Hormone Releasing Hormone with Lys8 and Arg8 and Substitutions in Positions 3 ,5 ,6 ,7 and 8d-Ala10] — N H 2 and [N -A c—D-2  
 Abstract    Antagonists of the luteinizing hormone releasing hormone (L H R H) of increased potency is a goal for control of ovulation. In the design and synthesis of 26 decapeptides, emphasis was given to analogs with Lys8 and Arg8 and with various substitutions in positions 3, 5, 6, 7 and 8. Two antagonists, [N — A c—D-2-Nal]-N H 2 showed 80-85% antiovulatory activity (A O A) at 0.25 (ig in the rat. The latter antagonist showed 60% A O A at 0.125 ^.g. O f four pairs of analogs with Arg8 and Lys8, respectively, two pairs favored Lys8 over Arg8 for potency. One pair showed negligible difference and another pair favored Arg8 over Lys8. There is specificity of substitution for potency. In other antagonists, d -3-Pal3, Tyr5 or Phe5, D-Arg6 and Leu7 or Nie7 or Val7 and Arg8 were variously effective substitutions for increase of potency and reduction of histamine release. 
  Reference    Z. Naturforsch. 41c, 1087—1091 (1986); received June 10 1986 
  Published    1986 
  Keywords    Luteinizing Hormone Releasing Hormone, Ovulation, Peptide, Antagonist, Histamine Release 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-1087.pdf 
 Identifier    ZNC-1986-41c-1087 
 Volume    41 
10Author    Ernst Bayer, Heribert Hellstern, Heiner EcksteinRequires cookie*
 Title    Synthese von immobilisierten Peptidfragmenten an Polystyrol-Polyoxyethylen zur Affinitätschromatographie Synthesis of Immobilized Peptide Fragments on Polystyrene-Polyoxyethylene for Affinity Chromatography  
 Abstract    Polystyrene-polyoxyethylene craft copolymers have been used for step-wise peptide synthesis. After completion of synthesis the protecting groups are cleaved under acidic conditions, where the polymer-peptide bond is stable. These gels in comparison to polystyrene peptide gels, show better properties for applications in affinity chromatography as well as synthesis on solid supports, because the advantageous properties of polystyrene beads are combined with the excellent spacer behavior of polyoxyethylene chains (mobility, solvation by water and organic solvents). Peptide gels with polylysine sequences have been synthesized as highly selective stationary phases for the separation of the homologous oligo desoxyribonucleotides (d7)n with n = 1—3. The principal possibilities of these gels for affinity chromatography 
  Reference    Z. Naturforsch. 42c, 455—460 (1987); received December 1 1986 
  Published    1987 
  Keywords    birthday Affinity Chromatography, Immobilization, Liquid-Solid-Phase, Peptides, Synthesis 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0455.pdf 
 Identifier    ZNC-1987-42c-0455 
 Volume    42 
11Author    Toshiro Matsui, Tomoyuki Oki, Yutaka OsajimaRequires cookie*
 Title    Isolation and Identification of Peptidic a-Glucosidase Inhibitors Derived from Sardine Muscle Hydrolyzate  
 Abstract    We report here the isolation of a-glucosidase (A G H) inhibitory peptides derived from sardine muscle hydrolyzate, which was prepared by digestion with Bacillus licheniformis alka­ line protease. A s a result of reversed-phase HPLC purification, two A G H inhibitory peptides were isolated from a D EA E -Sephadex A-25 column eluate. The peptides were identified as follows: V al-Trp (IC50 = 22.6 mM) and T ry -T y r -P r o -L e u (IC50 = 3.7 mM). A G H inhibitory studies of T r y -T y r -P r o -L e u and its derivatives demonstrated the importance of the tri­ peptide chain length as well as the hydrophobic aromatic amino acid tyrosine at the N-terminus, aliphatic amino acids at the C-terminus, as well as an amide proton from the peptide chain at the middle position of the tri-peptide to develop AGH inhibition activity. 
  Reference    Z. Naturforsch. 54c, 259 (1999); received August 25/October 5 1998 
  Published    1999 
  Keywords    a-G lucosidase Inhibition, Diabetes, Sardine Muscle Hydrolyzate, Peptide 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0259.pdf 
 Identifier    ZNC-1999-54c-0259 
 Volume    54 
12Author    N. Ghermani, C. Lecomte, N. BouhmaidaRequires cookie*
 Title    Electrostatic Potential from High-Resolution X-Ray Diffraction. Application to a Pseudo-Peptide Molecule  
 Abstract    The calculation of the electrostatic potential of a molecule removed from the crystal lattice is derived from the parameters obtained by a kappa refinement and by a Hansen-Coppens electron density model. These calculations in direct space are applied to N-acetyl-a,/?-dehydrophenylalanine; deformation potentials calculated by Fourier transformation are compared to those obtained in direct space. 
  Reference    Z. Naturforsch. 48a, 91—98 (1993); received December 23 1991 
  Published    1993 
  Keywords    Electrostatic potential, Kappa refinement, Multipole refinement, Peptides, Net charges 
  Similar Items    Find
 TEI-XML for    default:Reihe_A/48/ZNA-1993-48a-0091.pdf 
 Identifier    ZNA-1993-48a-0091 
 Volume    48 
13Author    Karl Folkers, Cyril Bowers, Xiao Shao-Bo, Pui-Fun, Louisa Tang, Minoru Kubota, Janusz Stepinski, Teresa KubiakRequires cookie*
 Title    Activities of Antagonists of the Luteinizing Hormone Releasing Hormone with Emphasis on Positions 1, 5 and 6 and on Positions 1, 2 and 3  
 Abstract    Analogs of the luteinizing hormone releasing hormone (LHRH) which are antagonists for controlling ovulation require potency and negligible release of histamine as a side effect. Forty analogs were designed, synthesized and bioassayed in two groups with emphasis upon positions 1, 5 and 6 and upon positions 1, 2 and 3. N-Ac-D-2-Nal 1 , D-pClPhe 2 , D-3-Pal 3 , Ser 4 , Tyr 5 . D-Lys 6 , 
  Reference    (Z. Naturforsch. 42b, 101—106 [1987]; received July 18 1986) 
  Published    1987 
  Keywords    Luteinizing Hormone Releasing Hormone, a«f/-Ovulatory Activity, Peptide, Antagonist, Histamine Release 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/42/ZNB-1987-42b-0101.pdf 
 Identifier    ZNB-1987-42b-0101 
 Volume    42 
14Author    H. Hauer, H.-D Lüdemann, R. JaenickeRequires cookie*
 Title    Free Activation Energies and Activation Volumes for the Amide Rotation in Some Peptides Studied by High Pressure 'H-High Resolution NMR  
 Abstract    From the pressure dependence o f !H high resolution N M R spectra o f two dipeptides (glycylsarcosine and N-acetyl-L-proline-NH-methylamide in the range 0.1 MPa <.p< . 150 MPa the activation volumes A V* for the am ide rotation are derived. This conform ational transition is characterized for glycylsarcosine by A V* = 4 ± 1 cm3 • m ol-1 and for. the proline derivative by AV* = 1 .5 ± 1 cm3 • m ol-1. From the given results the m axim um contribution o f proline cis ^ trans isomerisation to the pressure dependence o f the rate o f reactivation of proteins can be estimated to ~ — 30% per M Pa and proline present. 
  Reference    Z. Naturforsch. 37c, 51—56 (1982); received Septem ber 221981 
  Published    1982 
  Keywords    Activation Volume, High Pressure, NM R, Peptides, Proline-Isom erization 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-0051.pdf 
 Identifier    ZNC-1982-37c-0051 
 Volume    37 
15Author    H.Peter Matthiessen, H.Rainer MaurerRequires cookie*
 Title    Low Molecular Mass Inhibitors from Calf Thymus Selective for T-Lymphocyte Proliferation  
 Abstract    Endogenous factors preferentially inhibiting T-lympho-cyte proliferation were prepared from the acetone precipi­ tate of a 60% ethanol extract from calf thymus and their biochemical properties examined. By ultrafiltration the strongest lymphocyte-selective inhibition was found in the molecular mass range between 1 and 5 kDa. Fast protein liquid chromatography (FPLC) of this fraction on an anion exchange column eluted the lymphocyte inhibitors at 205—265 mM ammonium acetate. Staining procedures following IEF and TLC suggested, that the inhibitors may not be glycoconjugates or amines but small weakly acidic peptides (< 3 kDa). 
  Reference    Z. Naturforsch. 41c, 1131 (1986); received November 11 1985/July 18 1986 
  Published    1986 
  Keywords    Lymphocyte Proliferation Inhibitors, Calf Thymus, Peptides, Chalone, Colony Formation 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-1131_n.pdf 
 Identifier    ZNC-1986-41c-1131_n 
 Volume    41 
16Author    IvankaG. Stankova3, M. Ario, F. Simeonovb, Vera Maximova0, AngelS. Galabov0, EvgenyV. GolovinskydRequires cookie*
 Title    Synthesis and Anti-Virus Activity of Some Nucleosides Analogues  
 Abstract    New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a -g) and 3'-, 5'-thymidine (4 a -i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modifi­ cation on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only com­ pounds 4d and 4h showed a borderline effect against PsRV. 
  Reference    Z. Naturforsch. 54c, 75—83 (1999); received August lO/October 20 1998 
  Published    1999 
  Keywords    5-Bromo-2'-Deoxyuridine, Thymidine, Amino Acids, Peptides, Antiherpes Activity 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0075.pdf 
 Identifier    ZNC-1999-54c-0075 
 Volume    54