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'Oxidative Phosphorylation' in keywords Facet   section ZfN Section C  [X]
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1984 (1)
1975 (1)
1Author    G. Schäfer, A. Trebst, K. H. BüchelRequires cookie*
 Title    2-Anilino-1.3.4-thiadiazole, Hemmstoffe der oxidativen und photosynthetischen Phosphorylierung 2-Anilino-l,3,4-Thiadiazoles, Inhibitors of Oxidative and Photosynthetic Phosphorylation  
 Abstract    2-anilino-l,3,4-thiadiazoles carrying various substituents in the 5-position as well as in the benzene-ring were synthesized. The compounds were tested with rat-liver-mitochondria and with spinach-chloroplasts and revealed to be potent uncouplers of both, oxidative and photosynthetic phosphorylation, with p l50-values rangeing from 6.79 to 4.05. At higher concentration all compounds are inhibitors of the Hill-reaction. In mitochondria a fair correlation exists between pKa of the acidic NH-group and the un­ coupling activity; a maximum is obtained around pKa= 6 .8 , whereas in chloroplasts activity is shifted to more acid pKa-values. The compounds meet the requirements for uncouplers according to the chemi-osmotic theory, being lipophilic weak acids. N-methylation causes total loss of activity in mitochondrial oxidative phosphorylation. The inhibitory action on photosynthetic electron transport is located within photosystem II. This latter activity is almost independent of substituent effects in contrast to uncoupling of either respiratory-or photo-phosphorylation. 
  Reference    (Z. Naturforsch. 30c, 183 [1975]; eingegangen am 19. Dezember 1974) 
  Published    1975 
  Keywords    Oxidative Phosphorylation, Photophosphorylation, Uncouplers, Structure-function Correlation 
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 TEI-XML for    default:Reihe_C/30/ZNC-1975-30c-0183.pdf 
 Identifier    ZNC-1975-30c-0183 
 Volume    30 
2Author    T. V. Rao, U. C. BiswalRequires cookie*
 Title    Isolation and Respiratory A ssay o f Earthworm Body W all M itochondria  
 Abstract    Out o f several media tested, KC1 m edium contain­ ing BSA was found to be most suitable for isolation o f functionally efficient mitochondria from earthworms. Respiration and oxidative phosphorylation in isolated mitochondria are demonstrated in the presence o f cyto­ chrome c and BSA in reaction medium. Introduction — The details o f the respiratory m etabolism in earthworm are yet to be established. There are only a few contradictory reports on the nature o f its respiratory enzyme components [1], W hile, cytochrome oxidase, suc-cinoxidase, succinate dehydrogenase were identified in earthworm tissue homogenates, the presence o f Kreb's cycle enzymes could not be demonstrated. Very little information is available on earthworm m itochondria except one report where it is isolated in 0.44 M m annitol [2]. Mitochondria from invertebrates like insects and crustaceans are isolated and characterized [3, 4]. But such methods cannot be extended to earthworms as it is known that conditions for isolation and assay o f m itochondria are highly system specific [5]. 
  Reference    Z. Naturforsch. 39c, 853 (1984); received January 23 1984 
  Published    1984 
  Keywords    Earthworm Mitochondria, Isolation, Respiratory Assay, Metabolism, Oxidative Phosphorylation 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0853_n.pdf 
 Identifier    ZNC-1984-39c-0853_n 
 Volume    39