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'Neutrophils' in keywords Facet   Publication Year 1992  [X]
Facet   section ZfN Section C:Volume 047  [X]
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1Author    Z. Czuba, W. Krol, S. Scheller, J. ShaniRequires cookie*
 Title    Effect of Cinnamic and Acrylic Acids' Derivatives on Luminol-Enhanced Chemiluminescence of Neutrophils  
 Abstract    Fourteen derivatives o f cinnamic and acrylic acids were evaluated for their ability to modu­ late chemiluminescence, evoked by neutrophils that had been exposed to luminol and phorbol-myristate-acetate. Compounds with one or two hydroxyl groups on the phenyl ring demon­ strated significant inhibition o f the chemiluminescence, but this inhibition was diminished by methoxylation. Saturation of the double bond in the aliphatic chain of cinnamic acid at C6 -enhanced the chemiluminescence to a small degree. All three acrylic acid derivatives demon­ strated a marked inhibition of the luminol chemiluminescence, indicating that characteristics of the heterocyclic ring is of utmost importance in this activity. 
  Reference    Z. Naturforsch. 47c, 753—756 (1992); received March 25/May 25 1992 
  Published    1992 
  Keywords    Chemiluminescence, Luminol, Cinnamic Acid, Acrylic Acid, Neutrophils 
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 TEI-XML for    default:Reihe_C/47/ZNC-1992-47c-0753.pdf 
 Identifier    ZNC-1992-47c-0753 
 Volume    47 
2Author    W. Krol, J. Shani1, Z. Czuba, S. SchellerRequires cookie*
 Title    Modulating Luminol-Dependent Chemiluminescence of Neutrophils by Flavones  
 Abstract    The effect o f 14 flavones on luminol-dependent chemiluminescence o f neutrophils was stud­ ied in vitro. Chemiluminescence was used in this study as an indicator for the production o f a reactive oxygen species by neutrophils, stimulated by phorbol myristate acetate. While fla-vone-8-acetic acid, and most o f the com pounds tested, inhibited chemiluminescence, flavone and its 5-hydroxy-7-methoxy derivatives enhanced it by up to 150%. The m ost active inhibi­ tors o f photon emission were the glycosides. These results indicate that lipophilicity and some structural determinants modulate the chemiluminescent capacity o f neutrophils. 
  Reference    Z. Naturforsch. 47c, 889—8 (1992); received September 11 1992 
  Published    1992 
  Keywords    Chemiluminescence, Luminol, Radical Scavenging, Flavones, Neutrophils 
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 TEI-XML for    default:Reihe_C/47/ZNC-1992-47c-0889.pdf 
 Identifier    ZNC-1992-47c-0889 
 Volume    47