| | 1 | Author
| Z. Czuba, W. Krol, S. Scheller, J. Shani | Requires cookie* | | | Title
| Effect of Cinnamic and Acrylic Acids' Derivatives on Luminol-Enhanced Chemiluminescence of Neutrophils  | | | | Abstract
| Fourteen derivatives o f cinnamic and acrylic acids were evaluated for their ability to modu late chemiluminescence, evoked by neutrophils that had been exposed to luminol and phorbol-myristate-acetate. Compounds with one or two hydroxyl groups on the phenyl ring demon strated significant inhibition o f the chemiluminescence, but this inhibition was diminished by methoxylation. Saturation of the double bond in the aliphatic chain of cinnamic acid at C6 -enhanced the chemiluminescence to a small degree. All three acrylic acid derivatives demon strated a marked inhibition of the luminol chemiluminescence, indicating that characteristics of the heterocyclic ring is of utmost importance in this activity. | | | |
Reference
| Z. Naturforsch. 47c, 753—756 (1992); received March 25/May 25 1992 | | | |
Published
| 1992 | | | |
Keywords
| Chemiluminescence, Luminol, Cinnamic Acid, Acrylic Acid, Neutrophils | | | |
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| | | | | TEI-XML for
| default:Reihe_C/47/ZNC-1992-47c-0753.pdf | | | | Identifier
| ZNC-1992-47c-0753 | | | | Volume
| 47 | |
| 2 | Author
| W. Krol, J. Shani1, Z. Czuba, S. Scheller | Requires cookie* | | | Title
| Modulating Luminol-Dependent Chemiluminescence of Neutrophils by Flavones | | | | Abstract
| The effect o f 14 flavones on luminol-dependent chemiluminescence o f neutrophils was stud ied in vitro. Chemiluminescence was used in this study as an indicator for the production o f a reactive oxygen species by neutrophils, stimulated by phorbol myristate acetate. While fla-vone-8-acetic acid, and most o f the com pounds tested, inhibited chemiluminescence, flavone and its 5-hydroxy-7-methoxy derivatives enhanced it by up to 150%. The m ost active inhibi tors o f photon emission were the glycosides. These results indicate that lipophilicity and some structural determinants modulate the chemiluminescent capacity o f neutrophils. | | | |
Reference
| Z. Naturforsch. 47c, 889—8 (1992); received September 11 1992 | | | |
Published
| 1992 | | | |
Keywords
| Chemiluminescence, Luminol, Radical Scavenging, Flavones, Neutrophils | | | |
Similar Items
| Find | | | DEBUG INFO
| | | | | TEI-XML for
| default:Reihe_C/47/ZNC-1992-47c-0889.pdf | | | | Identifier
| ZNC-1992-47c-0889 | | | | Volume
| 47 | |
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