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'Neurotoxicity' in keywords Facet   Publication Year 2000  [X]
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1Author    Gerhard Bringmanna, Doris Feineis3, Ralph Brückner, Eva-Maria Petersb, Karl PetersbRequires cookie*
 Title    2-Hexanoyl-l-tribromomethyl-l,2,3,4-tetrahydro-/?-carboline: Crystal Structure Analysis of a Potent Inhibitor of Complex I of Mitochondrial Respiration  
 Abstract    The molecular structure of the title com pound 2-hexanoyl-l-tribromomethyl-l,2,3,4-tetra-hydro-/3-carboline (3), a potent inhibitor of complex I of the mammalian mitochondrial respi­ ratory chain, has been studied by single-crystal X-ray diffraction analysis. In the crystal, two heterochiral molecules of 3 (i.e., one R-and one S-configured molecule each) were found to be connected with one other in pairs via two intermolecular hydrogen bonds [0(215) • • • H(212)' and 0(215)' • • • H(212)] to form an overall achiral 'dimeric' subunit. 
  Reference    (Z. Naturforsch. 55b, 94—99 [2000]; received O ctober 21 1999) 
  Published    2000 
  Keywords    Crystal Structure, Bromal-Derived Tetrahydro-ß-carbolines Mitochondrial Respiration, Parkinson's Disease, Neurotoxicity 
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 TEI-XML for    default:Reihe_B/55/ZNB-2000-55b-0094.pdf 
 Identifier    ZNB-2000-55b-0094 
 Volume    55