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1983 (1)
1Author    Manfred Gerlach, Peter Jutzi, Johannes-Peter Stasch, Horst PrzuntekRequires cookie*
 Title    Synthese und pharmakologische Eigenschaften von silylierten Dopaminen und 4.4-Diphenylpiperidinen Synthesis and Pharmacological Properties of Silylated Dopamines and 4,4-Diphenylpiperidines  
 Abstract    Syntheses for the bis-O-trimethylsilylated (2), the tris-0,0,N-trimethylsilylated (3) and the tetrakis-0,0,N,N-trimethylsilylated dopamine (4) are described. The preparation of some N-trialkylsilylated 4,4-diphenylpiperidines 6-8 and of the N-triphenylsilylated piperidine 9 is also reported. The silylation of these neuropharmaca enhances their lipo-philic character. Preliminary pharmacological investigations show the desired central effect of these compounds. The silylated dopamines 3 and 4 influence positively the rigid akinetic syndrom, which was induced by reserpine. The silylated 4,4-diphenylpiperidines 6-9 show the same effect on the content of neurotransmitters in the rat brain as the Anti-parkinson drug l-ier£-butyl-4,4-diphenylpiperidine (budipine). 
  Reference    Z. Naturforsch. 38b, 237—242 (1983); eingegangen am 1. Oktoder 1982 
  Published    1983 
  Keywords    Silylated Dopamines, Silylated 4, 4-Diphenylpiperidines, Syntheses, Pharmacological Properties, Neuropharmaca 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-0237.pdf 
 Identifier    ZNB-1983-38b-0237 
 Volume    38