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1996 (1)
1Author    M.J M Artín Calero, C.La Casa, V. Motilva, A. L. Ópez, C. Alarcó, La De, LastraRequires cookie*
 Title    Healing Process Induced by a Flavonic Fraction of Bidens aurea on Chronic Gastric Lesion in Rat. Role of Angiogenesis and Neutrophil Inhibition  
 Abstract    The aim of this study was to elucidate the mechanism of the healing process mediated by the flavonic fraction of Bidens aurea on chronic gastric ulceration induced by 5% acetic acid in rats. The diethyl ether extract (125 and 62.5 mg kg-1 body weight) was administered in a single doses, 7 and 14 days after provocation of lesions. O ur results demonstrated that both doses significantly decreased the macro and microscopic ulcer index. Usually after 14-days treatment the lesions were found completely covered with regenerative epithelium and also an important proliferation of blood vessels was observed. Myeloperoxidase (M P O) activity was assayed and used as an index of leucocyte infiltration. Application of acetic acid pro­ duced a significant increase of this activity 7 days after induction of chronic injury. A d m in ­ istration of 125 mg kg 1 of the ether extract provoked a sharp reduction on the enzymatic activity at the same period. After 14 days, this decrease was higher with both doses (p<0.001). In addition, the macroscopic examination showed a drastic reduction of leucocyte infiltration in treated groups. These results suggest that the recovery of vascularization of the ulcerated area and the decrease of neutrophil infiltration are involved in the antiulcerogenic effect of the flavonoid fraction of Bidens aurea. 
  Reference    Z. Naturforsch. 51c, 570—577 (1996); received March 11/May 21 1996 
  Published    1996 
  Keywords    Bidens aurea, Flavonoids Chronic Gastric Ulcer, Neutrophils, Myeloperoxidase Activity 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0570.pdf 
 Identifier    ZNC-1996-51c-0570 
 Volume    51