| | 1 | Author
| Joachim Hilfenhaus, HermannE. Karges | Requires cookie* | | | Title
| Growth Inhibition of Human Lymphoblastoid Cells by Interferon Preparations, Obtained from Human Leukocytes  | | | | Abstract
| The growth inhibition of human lymphoblastoid cells by human interferon preparations (HIF) and a mock-interferon preparation (Mock-IF) was studied. HIF was induced in suspensions of primary human leukocytes by Newcastle Disease Virus. Mock-IF was prepared from uninduced cell suspension of a comparable batch. The highest degree of inhibition of cell propagation was ob tained on the EBV producer line P3HR1, the inhibition of the cell lines Raji and SKL 1 was significantly lower, no effect was observed on the cell line RPMI 1788 originating from a healthy donor. Mock-IF also caused a growth inhibition but to a lower degree as HIF. HIF and Mock-IF are similar in the following properties: 1. Stability at pH 2 at 4 °C for four days, 2. sensitivity to tryptic digestion, and 3. molecular weights in the range between 5,000 and 40,000 daltons. | | | |
Reference
| (Z. Naturforsch. 29c, 618 [1974]; received May 13/July 11 1974) | | | |
Published
| 1974 | | | |
Keywords
| Interferon, Mock-Interferon, Growth Inhibition, Human Lymphoblastoid Cells, Epstein Barr Virus | | | |
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| default:Reihe_C/29/ZNC-1974-29c-0618.pdf | | | | Identifier
| ZNC-1974-29c-0618 | | | | Volume
| 29 | |
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