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1998 (1)
1Author    M. Stohrer3, A. Ndrea Eichinger3, M. Schlachter5, M. Stangassinger3, F. Hoffmann, -La Roche LtdRequires cookie*
 Title    Protective Effect of Vitamin E in a Rat Model of Focal Cerebral Ischemia  
 Abstract    Under certain pathological conditions such as cerebral ischemia and reperfusion the occur­ rence of free radicals is remarkably increased. However, only very little information is avail­ able on their quantitative relevance for the pathophysiology and final outcom e of diseases. The aim of the present study was to evaluate the contribution o f oxygen radicals in the pathogenesis of a stroke. For this purpose a rat model for stroke was used. Two of three vitamin E deficient groups were repleted with different dosages of DL-a-tocopherylacetate. N o signs of vitamin E deficiency could be observed. However, the weight gain during reple­ tion was increased in the vitamin E repleted groups. Brain infarction was created by occlusion o f the right middle cerebral artery (M CAO) for two hours. After 24 hours the measurements o f infarct volum es were taken. The infarct volume of the group with the highest repletion dosage was significantly reduced by 81%. This was also expressed in a higher rate of gait disturbances after MCAO o f the deficient animals. The control of vitamin E status exhibited a similar repletion-dependent level in plasma and brain. These results strongly support the hypothesis that the generation of oxygen radicals occurring during reperfusion is an impor­ tant aspect of the pathophysiological mechanism in brain infarction. 
  Reference    Z. Naturforsch. 53c, 273—2 (1998); received D ecem ber 19 1997/January 22 1998 
  Published    1998 
  Keywords    Vitamin E, Middle Cerebral Artery Occlusion, Rat, Brain Infarct Volume, Oxygen Radicals 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0273.pdf 
 Identifier    ZNC-1998-53c-0273 
 Volume    53