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'Methotrexate' in keywords
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1979 (1)
1976 (1)
1Author    J. Freise, P. Magerstedt, F. W. SchmidtRequires cookie*
 Title    Die in vitro und in vivo Stabilität des Einschlusses von Methotrexat in negativ geladenen Liposomen nach Sterilfiltration The in vitro and in vivo Stability of the Entrapment of Methotrexate in Negatively Charged Liposomes after Sterile Filtration  
 Abstract    The preparation of sterile artificial liposomes (phosphatidylcholine: cholesterol: dicethylphos-phate = 5 : 5 : l) by Millipore® filtration is described. Conditions for storing liposome entrapped Methotrexate have been found which allow storage of the drug in the entrapped form over a period of at least 4 months. It is shown that intravenously injected liposome entrapped Metho­ trexate is retained for at least 15 hours in the particulate form. During this time no free Metho­ trexate is detectable in the blood. 
  Reference    Z. Naturforsch. 34c, 114 (1979); eingegangen am 16. August/10. November 1978 
  Published    1979 
  Keywords    Methotrexate, Liposomes, Endocytosis, Cell Membrane 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0114.pdf 
 Identifier    ZNC-1979-34c-0114 
 Volume    34 
2Author    U. Zimmermann, G. PilwatRequires cookie*
 Title    Organspezifische Applikation von pharmazeutisch aktiven Substanzen über zellulare Trägersysteme Organ Specific Application of Drugs by Means of Cellular Capsule Systems  
 Abstract    It is suggested to use living cells (red blood cells, lymphocytes and leucocytes) as drug delivery systems for temporal and spatial drug administration in human therapeutics and diagnosis. The effectiveness of drug loaded cells is demonstrated for the drug methotrexate which is used in cancer treatment. Red blood cells are loaded with methotrexate using the dielectric breakdown technique. Dielec­ tric breakdown leads to a transient increase of permeability of the cell membrane. Red blood cells loaded with tritium-labelled methotrexate were injected into mice and the activity level was measured in several organs as a function of time. It is shown that with this drug delivery system more than 50% of the drug (after 10 min) can be accumulated in the liver and that a high activity level can be sustained in this organ for more than 3 hours. On the other hand, administra­ tion of this drug by injecting solutions in the usual manner leads only to an 25% accumulation of methotrexate (after 10 min) in the liver. The drug is excreted completely after 1 to 2 hours. It is proposed to load red blood cells simultaneously with para-or ferromagnetic substances to obtain organ-specificity for any selected site of the body. 
  Reference    (Z. Naturforsch. 31c, 732 [1976]; eingegangen am 24. September 1976) 
  Published    1976 
  Keywords    Dielectric Breakdown, Red Blood Cells, Methotrexate, Controlled Drug Release, Organspecificity 
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 TEI-XML for    default:Reihe_C/31/ZNC-1976-31c-0732.pdf 
 Identifier    ZNC-1976-31c-0732 
 Volume    31