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1983 (1)
1982 (1)
1979 (2)
1Author    Michael Schneider, Martin Wenzel, Gerd SchachschneiderRequires cookie*
 Title    Enzym atische H ydroxylierung von R uthenocen und O sm ocen durch Leber-M ikrosom en Enzymatic Hydroxylation of Ruthenocen and Osmocene  
 Abstract    In buffer solution (pH 7,4) ruthenocene and osmocene are far more stable than ferrocene. The metallocenes ruthenocene and osmocene are metabolized by microsomes of mouse liver in the presence o f NADPH and 0 2. The Ä'if-values are similar for both metallocenes, the rate of metabolism is higher for osmocene that for ruthenocene. 
  Reference    Z. Naturforsch. 37c, 136 (1982); received August 201981 
  Published    1982 
  Keywords    Metallocenes, Radiodiagnostics, Osmium, Ruthenium, Hydroxylation 
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 TEI-XML for    default:Reihe_C/37/ZNC-1982-37c-0136_n.pdf 
 Identifier    ZNC-1982-37c-0136_n 
 Volume    37 
2Author    Petra Köpf-Maier, Hartmut KöpfRequires cookie*
 Title    Vanadocen-dichlorid - ein weiteres Antitumor-Agens aus der Metallocenreihe Vanadocene Dichloride -Another Antitumor Agent from the Metallocene Series  
 Abstract    The antitumor activity of vanadocene dichloride is investigated against Ehrlich ascites tumor in CFi mice. The application of 80 or 90 mg/kg 24 h after transplantation achieves 100% tumor inhibition until day 30. On treatment with higher doses death of an increasing number of animals is caused by substance toxicity. The results of this study indicate that vanadocene dichloride exhibits antineoplastic properties similar to those found for titanocene dichloride and cis-dichlorodiammine-platinum(II). 
  Reference    Z. Naturforsch. 34b, 805—807 (1979); eingegangen am 15. März 1979 
  Published    1979 
  Keywords    Vanadocene Dichloride, Metallocenes, Antitumor Activity, Ehrlich Ascites Tumor 
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 TEI-XML for    default:Reihe_B/34/ZNB-1979-34b-0805.pdf 
 Identifier    ZNB-1979-34b-0805 
 Volume    34 
3Author    Petra Köpf, -M Aier, M. Anfred Leitner, R. Olf Voigtländer, H. Artm, K. ÖpfRequires cookie*
 Title    Molybdocen-dichlorid als Antitumor-Agens Molybdocene D ichloride as an A ntitum or Agent  
 Abstract    The antitum or activity o f molybdocene dichloride is tested against Ehrlich ascites tum or in CFj mice. The application o f 75 or 100 m g/kg 24 h after transplantation achieves 100% tum or in h ib i­ tion until day 30. Following the d° and d 1 metallocene dichlorides o f titanium and vanadium , molybdocene d i­ chloride is the First analogous d 2 system revealing sim ilar antineoplastic properties. 
  Reference    Z. Naturforsch. 34c, 1174 (1979); eingegangen am 5. Juni/19. Septem ber 1979 
  Published    1979 
  Keywords    Molybdocene Dichloride, Metallocenes, A ntitum or Activity, Ehrlich Ascites Tum or 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-1174.pdf 
 Identifier    ZNC-1979-34c-1174 
 Volume    34 
4Author    Martin Wenzel, G. Ert SchachschneiderRequires cookie*
 Title    Analoga des Hippurans: [103RulRuthenocenoyl-glycin-Derivate. Synthese, Organ-Verteilung und Clearance Analogue of Hippuran: Labelled Ruthenocenoyl-glycin. Synthesis, Organ Distribution and Clearance  
 Abstract    The analogue o f hippuric acid, ruthenocenoyl-glycine was synthesized and labelled with the y-emitter 103Ru. As a by-product o f the synthesis the labelled diam ide from ruthenocene-dicarbonic acid and glycine was gained. With these ruthenocene derivatives the organ distribu­ tions in mice and rats were measured. All ruthenocene-glycine derivatives showed prim ary a high kidney accum ulation followed by very rapid renal excretion. After application o f the cytostatic PtCl2(N H 3) 2, causing toxic effects in the kidney o f m ice, the excretion of ruthenocenoyl-glycine is decreased. Biochem ical data suggest the use of labelled ruthenocenoyl-glycine as a substitute for Iodo-labelled hippuran. 
  Reference    Z. Naturforsch. 38c, 806 (1983); received May 2/Ju ly 19 1983 
  Published    1983 
  Keywords    Ruthenium Isotopes, Metallocenes, Kidney, R adiopharm aceuticals, Organ D istribution 
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 TEI-XML for    default:Reihe_C/38/ZNC-1983-38c-0806.pdf 
 Identifier    ZNC-1983-38c-0806 
 Volume    38