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'Mass Spectra' in keywords Facet   Publication Year 1993  [X]
Facet   section ZfN Section B:Volume 048  [X]
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1993[X]
1Author    Ion Neda, Michael Farkens, Axel Fischer, PeterG. Jones, R. Einhard SchmutzlerRequires cookie*
 Title    Zur Chemie der l,3,5-Triaza-2-phosphinan-4,6-dione, Teil V* Darstellung der Phosphoryl(III)(A4P)-und Thiophosphoryl(III)(A4P)-Derivate der l,3,5-Triaza-2-phosphinan-4,6-dione. Umsetzungen mit Ketonen  
 Abstract    Chemistry of the l,3,5-Triaza-2-phosphinane-4,6-diones, Part V Synthesis of Phosphoryl(III)(^4P) and Thiophosphoryl(III)(/!.4P) Derivatives of 1.3.5-Triaza-2-phosphinane-4,6-diones. Reactions with Ketones 18. M ärz 1993 1.3.5-Trimethyl-Substituted l,3,5-Triaza-2-oxo-and 1.3.5-Triaza-2-thio-2/.4-phosphinane-4, 
  Reference    Z. Naturforsch. 48b, 860—866 (1993); eingegangen am 
  Published    1993 
  Keywords    6-diones, N M R Spectra, Mass Spectra, X-Ray 
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 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-0860.pdf 
 Identifier    ZNB-1993-48b-0860 
 Volume    48 
2Author    WilfriedA. Königa, Holger Faascha, Holger Heitsch3, Cornelia Colberga, BjörnM H AusenRequires cookie*
 Title    Synthese von seitenkettenmodifizierten Analogen des Allergens Primin Synthesis of Side-Chain-Modified Analogues of the Allergen Primin  
 Abstract    Benzoquinones such as primin (2-methoxy-6-pentyl-l ,4-benzoquinone) from Primula ob-conica H A N C E (Primulaceae) are known to be strong sensitizers and thus the source of severe allergic contact derm atitis (cell-mediated type of allergy). In order to determine the relation­ ship between sensitizing capacity and chemical structure the synthesis of 19 side-chain-modi-fied analogues of primin was carried out. With each of these primin derivatives 10 guinea pigs were sensitized using a modified FCA-m ethod (FCA = Freund's complete adjuvant). Elicita­ tion was done open epicutaneously with 0.001 molar concentrations. In these sensitization ex­ periments 2-methoxy-6-alkyl-l ,4-benzoquinones (chain length C , -C 15) showed ascending sen­ sitizing potency with increasing number of the side chain carbon atom s reaching maximum activity at an alkyl chain of 10 to 11 carbons. Beyond this point a decrease o f the sensitizing potency in correlation with a further prolongation of the side chain was observed. 
  Reference    Z. Naturforsch. 48b, 387—393 (1993); eingegangen am 13. Juli 1992 
  Published    1993 
  Keywords    Primin, 6-Alkyl-2-methoxy-l, 4-benzoquinones, Allergens, 'H N M R Spectra, Mass Spectra 
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 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-0387.pdf 
 Identifier    ZNB-1993-48b-0387 
 Volume    48