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1998 (1)
1997 (2)
1Author    Robert Ruloff, Thomas Gelbrich, Joachim Sieler, Eberhard Hoyer, Lothar BeyerRequires cookie*
 Title    Strukturen zweier isomerer Gadolinium(III)-Polyaminopolycarboxylate -Argumente für signifikante Unterschiede ihrer ^-NM R-Relaxation Structures of Two Isomeric Gadolinium(III) Polyamino Polycarboxylates -Relation to their Significant Differences in 'H NMR Relaxation  
 Abstract    We present preparation and X-ray crystal structures of gadolinium(III) complexes with two isomeric ligands; triethylenetetraminehexaacetic acid, H6ttha, and tris(2-aminoethyl)amine-hexaacetic acid, H6ttaha, respectively. In case of [C(NH2)3]2[Gd(Httha)] • 5 H20 (1) the inner coordination sphere is made up of 9 donor atoms of the ligand and reflects the low efficiency in accelerating 'H NMR relaxation of an aqueous solution. In case of [C(NH2)3]3[Gd(ttaha)] • 3 H20 (2) the coordination number of 9 is realized via 7 donor atoms of the ligand and 2 oxygen atoms of a pending acetate group of the adjacent complex. Luminescence studies in aqueous solution confirm replacement of this acetate group by 2 water molecules. The relaxivity of [Gd(Httaha)]2-is 7.3 ± 0.1 mM ~'s -1 as determined at pH = 7.2, 20 MHz and 40°C. 
  Reference    Z. Naturforsch. 52b, 805—809 (1997); eingegangen am 23. April 1997 
  Published    1997 
  Keywords    Gadolinium(III) Chelates, Solid State Structures, Lanthanoids, 'H NMR Relaxivity, Magnetic Resonance Imaging 
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 TEI-XML for    default:Reihe_B/52/ZNB-1997-52b-0805.pdf 
 Identifier    ZNB-1997-52b-0805 
 Volume    52 
2Author    Robert Ruloff, Thomas Gelbrich, Eberhard Hoyer, Joachim Sieler, Lothar BeyerRequires cookie*
 Title    Gesteuerte Kristallisation des Gadolinium(III)-Komplexes von Diethylentriaminpentaacetat: Monomere und dimere Struktur Controlled Crystallization of the Gadolinium(III) Complex of Diethylenetriamine- Pentaacetate: Monomeric and Dimeric Structure  
  Reference    Z. Naturforsch. 53b, 955—959 (1998); eingegangen am 29. Mai 1998 
  Published    1998 
  Keywords    Gadolinium(III) Chelates, Diethylenetriamine-Pentaacetate Complexes, Coordinated Water, Solid State Structures, Magnetic Resonance Imaging 
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 TEI-XML for    default:Reihe_B/53/ZNB-1998-53b-0955.pdf 
 Identifier    ZNB-1998-53b-0955 
 Volume    53 
3Author    M. Anuela Wagner3, R. Obert Ruloffb, EberhardH. Oyerb, Wilfried Gründer3Requires cookie*
 Title    New Gadolinium Complexes as Magnetic Resonance Imaging -Contrast Agents  
 Abstract    We have investigated the physicochemical and paramagnetic properties of the new gado­ linium complexes of N-(pyrid-2-yl-m ethyl)-ethylenediam ine-N,N',N'-triacetic acid (Gd-PED TA) and N -tris(2-am in oeth yl)am in e-N \N \N ",N ",N "\N '"-hexaacetic acid (Gd-TTA H A). The relaxivities as well as the thermodynamic and conditional stability constants of these complexes with respect to the physiological relevance were determined and discussed in comparison with the commercially available gadolinium(III) diethylenetriaminpentaacetic acid/ gadopentate dimeglumine (G d-DTPA, Magnevist®). In case of Gd-TTAHA a twofold higher relaxivity and a com plex stability similar to Gd-DTPA were determined. It is shown, that lower concentrations o f G d-TTA H A are sufficient for the same signal enhancement in the Tt-weighted MR image compared with Gd-DTPA and, thus, the use of the new contrast agent Gd-TTAHA should diminish risks for health. Therefore, Gd-TTAHA might be used potentially as a new contrast agent for clinical MRI application. 
  Reference    Z. Naturforsch. 52c, 508 (1997); received April 23/June 4 1997 
  Published    1997 
  Keywords    Gadolinium(III) Complexes, Contrast Agents, Relaxivities, Complex Stability Constants, Magnetic Resonance Imaging 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0508.pdf 
 Identifier    ZNC-1997-52c-0508 
 Volume    52