| 2 | Author
| Yoshim Itsu Yamazaki, AkihikoM. Aruyam, Kuniaki Hosono, Takanori Higashihara, HarumI. Kobayashi | Requires cookie* | | Title
| Asymmetrie Reduction of Synthetic Ketones by Marine Microorganisms  | | | Abstract
| Three strains o f bacteria reducing (trifluoroacetyl)ferrocene (3) to optically pure (R)-2,2,2-trifluoro-l-hydroxyethylferrocene (4) and one bacterial strain reducing 3 to (5^)-4 o f moderate optical purity were isolated from sea-water collected at the coastal areas in Ibaraki prefecture o f Japan. The former three strains were identified as Micrococcus lylae, M icrococcus luteus, and D eleya marina and the latter as Bacillus licheniformis. These strains also asymmetrically reduced som e other synthetic ketones, e.g., 2,2,2-trifluoroacetophenone (7) and phenyl tri-methylsilyl ketone (9). Further screening o f microorganisms capable o f reducing 3 was done with bacteria isolated from sea-water o f the deep sea (Okinawa trough, Japan trench, and Mariana trough) and o f the pelagic areas (Indian Ocean and South China Sea). M ost o f these marine strains preferentially reduced 3 to (/?)-4 similar to the coastal strains, but the frequency o f finding very highly enantioselective strains (i.e., those forming 4 o f > 90% e.e.) was remark ably high in several sites o f the deep sea and pelagic areas as compared with the coast and terrestrial environment. | | |
Reference
| Z. Naturforsch. 48c, 451 (1993); received December 23 1992/February 24 1993 | | |
Published
| 1993 | | |
Keywords
| M icrobial, Asymmetric, Reduction, Marine, M icroorganism | | |
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| default:Reihe_C/48/ZNC-1993-48c-0451.pdf | | | Identifier
| ZNC-1993-48c-0451 | | | Volume
| 48 | |
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