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1991 (1)
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1Author    W. Erner, K. Roll, StefanP. Ostius, F. Riedhelm, S. ChneiderRequires cookie*
 Title    Proliferation Kinetics and Metabolic Features of in vitro Grown Ehrlich Ascites Tumor Cells in the Presence of Exogenous Pyruvate  
 Abstract    The proliferation o f in vitro grown Ehrlich ascites tum or cells is inhibited by pyruvate concen­ trations > 2 m M . In the presence o f 4 —5 m M pyruvate the growth is reduced to about 50% , in the presence o f 20 mM to about 5 — 10%. Viability o f the cells is not severely affected. Increase o f D N A corresponds to the cell growth. On recultivation in pyruvate free standard m edium , growth is nearly normal. Flow cytometric analyses o f the proliferation kinetics of the cells in the presence o f 20 m M pyruvate revealed a retardation o f the passage o f all phases o f the cell cycle. N o phase specific effects could be detected though the S-and G 2M -p hase are more afflicted than G l . The growth inhibition o f E A T cells by pyruvate seem s to depend on the presence of glucose. Exogenous pyruvate (> 1 —2 m M) causes an activation o f pyruvate dehydrogenase, a reduction o f lactate production from glucose and a stimulation o f lipid biosynthesis; the N A D /N A D H ratio of the cells is reduced and a rise o f glycolytic interm ediates beyond glyceraldehyde-3-phosphate dehydrogenase is observed. Maximal activation of pyruvate dehydrogenase by non toxic concen­ trations o f dichloroacetate is also accom pagnied by an inhibition o f cell growth. It is suggested that an increase o f glyceraldehyde-3-phosphate level and the changes in the redox state o f the cells are o f relevance for the inhibition o f cell growth by pyruvate. 100—500 ^im exogenous glycer-aldehyde-3-phosphate strongly inhibited cell growth. 
  Reference    Z. Naturforsch. 41c, 787—794 (1986); received March 20 1986 
  Published    1986 
  Keywords    Ehrlich A scites Tumor Cells, Growth Inhibition, Pyruvate, M etabolism 
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 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-0787.pdf 
 Identifier    ZNC-1986-41c-0787 
 Volume    41 
2Author    G. Bärenwald, B. Schneider, H. R. SchütteRequires cookie*
 Title    Comparative Investigations on the Metabolism of the Herbicide 2-(2,4-Dichlorophenoxy)-propionic Acid in Plants and Cultured Cells of Tomato  
 Abstract    A kadem ie der W issenschaften der D D R , Institut für B iochem ie der Pflanzen, W einberg 3, H alle/ Saale. The m etabolism o f [ l -l4C ]2-(2,4-dichlorophenoxy)-propionic acid was studied in excised plants and cell suspension cultures o f tom ato. It was rapidly taken up and m etabolized by both the plants and the cultured cells. The m etabolites, isolated by extraction with aqueous acetone, separated and purified by TLC and H PLC, were identified by chem ical and spectrometric methods. C onju­ gates with carbohydrates were detected. G lucose, diglucose as the main conjugating m oiety, and triglucose were found as carbohydrate com ponents within the conjugates. Alm ost the same conjugates occurred in plants and cultured cells. 
  Reference    Z. Naturforsch. 44c, 233—236 (1989); received O ctober 24 1988/January 16 1989 
  Published    1989 
  Keywords    H erbicide, M etabolism, C onjugation, Cell Suspension Culture 
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 TEI-XML for    default:Reihe_C/44/ZNC-1989-44c-0233.pdf 
 Identifier    ZNC-1989-44c-0233 
 Volume    44 
3Author    DaleL. ShanerRequires cookie*
 Title    Mode of Action of Naphthalic Acid as a Safener for Imazethapyr  
 Abstract    The tolerance of maize to root-applied imazethapyr can be increased by pretreating plants with the potassium salt of naphthalic acid (NAK). This safening effect appears to be the result o f N A K stimulating the ability of maize to rapidly metabolize imazethapyr to 5'-hydroxy-ethyl-imazethapyr, possibly through a mixed function oxidase. The safening effect of N AK can be antagonized by 1-aminobenzotriazole (ABT), a mixed function oxidase inhibitor. The increased rate of hydroxylation of imazethapyr to 5'-hydroxyethyl-imazethapyr immobilizes the herbicide in the root system which decreases the accum ulation of herbicide in the meriste-matic tissue. This decreased accumulation, in turn, lowers the phytotoxicity of imazethapyr on maize. 
  Reference    Z. Naturforsch. 46c, 893—896 (1991); received M arch 26 1991 
  Published    1991 
  Keywords    Maize, Imidazolinone, Safeners, Naphthalic Acid, Naphthalic Anhydride, M etabolism 
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 TEI-XML for    default:Reihe_C/46/ZNC-1991-46c-0893.pdf 
 Identifier    ZNC-1991-46c-0893 
 Volume    46