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1998 (1)
1Author    H. Kleszczyńska3, J. Ł. Uczyńskib, S. Witekb, S. PrzestalskiaRequires cookie*
 Title    Hemolytic Activity of Aminoethyl-dodecanoates  
 Abstract    The effect of new lysosomotropic compounds on red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In earlier studies it was shown that the compounds inhibit the growth of yeast and plasma membrane H+-ATPase activity. The study was per­ formed with eight aminoethyl esters of lauric acid variously substituted at nitrogen atom. Esters of dodecanoic acid were chosen for study because at that chain length dimethylamino-ethyl esters showed maximum activity. The hemolytic activity of the substances studied exhib­ its diversified activity in their interaction with the erythrocyte membrane: they differ in hemolytic activity and affect membrane fluidity differently. Erythrocyte membrane fluidity changes under the effect of those compounds which possess highest hemolytic activity. The hemolytic activity of the aminoesters investigated was found to follow a sequence that de­ pended on basicity (i.e. ability of the protonated form formation) of the compound and its polar head group size. The most active are the compounds that possess not more than four carbon atoms substituted at nitrogen and highest pKa value. 
  Reference    Z. Naturforsch. 53c, 101 (1998); received November 3/December 1 1997 
  Published    1998 
  Keywords    Lysosomotropic Substances, Aminoesters of Fatty Acids, Erythrocyte Membrane, Hemolytic Activity, Fluidity 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0101.pdf 
 Identifier    ZNC-1998-53c-0101 
 Volume    53