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'Liquid Chromatography' in keywords Facet   Publication Year 1995  [X]
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1Author    Reinhold Tacke3, Dirk Reichel3, KurtG. Ünther5, StefanM. ErgetbRequires cookie*
 Title    The First Liquid-Chromatographic Separation of the (/?)-and (S)-Enantiomers of a Chiral Silanol, Silane and Germane  
 Abstract    The racemic mixtures of the muscarinic antagonists cyclohexyl(phenyl)(2-pyrrolidino-ethyl)silanol (sila-procyclidine, rac-1), cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)-silane (rac-2) and cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)germane (rac-3) were resolved by analytical liquid chromatography (H PLC) using chemically modified cellulose (1) or amylose (2, 3) as the chiral stationary phase. This chromatographic method was used for the quantitative determination of enantiomeric purity of the (R)-and (S)-enantiomers of 1 -3 , which were obtained by preparative resolution with chiral auxiliary agents. Further­ more, the enantiomeric purity o f these samples was established by 13C NM R studies using chiral shift reagents. According to these studies, the resolved antipodes of 1 -3 (obtained by preparative resolution) were almost enantiomerically pure [HPLC: >98.2% ee ((R)-3) to 99.4% ee ((tf)-l, (S)-l); NMR: > 97% ee]. 
  Reference    Z. Naturforsch. 50b, 568 (1995); received October 31 1994 
  Published    1995 
  Keywords    Chiral Silanol, Chiral Silane, Chiral Germane, Liquid Chromatography, Separation o f Enantiomers 
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 TEI-XML for    default:Reihe_B/50/ZNB-1995-50b-0568.pdf 
 Identifier    ZNB-1995-50b-0568 
 Volume    50