| | 1 | Author
| Claus Fuchs, Gerhard Spiteller | Requires cookie* | | | Title
| Iron Release from the Active Site of Lipoxygenase  | | | | Abstract
| In the course of the lipoxygenase-catalyzed transformation of linoleic acid to 135-hydro-p eroxy-9Z ,ll£'-octad ecad ien oic acid, iron ions are liberated. This iron release has been de termined using a spectrophotom etric assay based on the complexation of ferrous iron by 3-(2-pyridyl)-5,6-bis-(4-phenylsulfonic acid)-l,2,4-triazine disodium salt (ferrozine). Further comparative measurements demonstrated that iron release correlates to deficient oxygen supply. We speculate that release of iron ions is caused by modifications of histidine residues located at the active site of the enzyme. Liberation of iron ions may be responsible for increased generation of lipid peroxidation (L P O) products observed after a myocardial in farction since iron ions induce nonenzymic LPO processes. | | | |
Reference
| Z. Naturforsch. 55c, 643 (2000); received March 23/April 17 2000 | | | |
Published
| 2000 | | | |
Keywords
| Lipoxygenase, Iron Release, Myocardial Infarction | | | |
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| default:Reihe_C/55/ZNC-2000-55c-0643.pdf | | | | Identifier
| ZNC-2000-55c-0643 | | | | Volume
| 55 | |
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