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2001 (1)
1Author    M. Einrad Boll, LutzW D Weber, E.Berhard Becker, Andreas StampflRequires cookie*
 Title    Hepatocyte Damage Induced by Carbon Tetrachloride: Inhibited Lipoprotein Secretion and Changed Lipoprotein Composition  
 Abstract    Changes of lipoprotein secretion and composition in response to CC14 treatment were studied in monolayer cultures of rat primary hepatocytes. (1) CC14 decreased secretion of very low density lipoproteins (V L D L) by about 85%, while high density lipoprotein (H D L) secretion was less affected (about 40%). The effect was concentration-dependent. (2) CC14 significantly inhibited secretion of V LD L-and H D L-asso-ciated triglycerides and cholesterol esters. V LD L-and HD L-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apoli-poproteins B48, B 100, E, C, and A-I. CC14 reduced secretion of apoproteins associated with V L D L by almost 20%, and by about 75% when associated with H D L. The de novo synthesis of apolipoproteins was attenuated by CC14. (4) CC14 caused variations in the apolipoprotein composition in V L D L and HDL. CC14 intoxication of the liver affected the morphology and/or function of the lipoproteins, which drastically impaired their ability to act as transport vehicles for lipids from the liver to the circulation. 
  Reference    Z. Naturforsch. 56c, 283 (2001); received October 13/November 29 2000 
  Published    2001 
  Keywords    Liver Damage, Carbon Tetrachloride, Lipoprotein Secretion 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0283.pdf 
 Identifier    ZNC-2001-56c-0283 
 Volume    56