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1999 (1)
1998 (1)
1Author    H. Kleszczyńska3, M. O. Święcimskab, S. W. Itekb, S. PrzestalskiaRequires cookie*
 Title    Inhibition of Lipid Peroxidation in the Erythrocyte Membrane by Quaternary Morpholinium Salts with Antioxidant Function  
 Abstract    The antioxidant activity of five new compounds from a group of quaternary ammonium salts with antioxidant function has been investigated. The effect of the compounds on the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation was studied. It was found that all the salts used decreased oxidation of the lipids in the erythrocyte mem­ brane. The antioxidant activity of the ammonium salts studied increased with their alkyl chain length. Three compounds with the longest alkyl chains were the most active antioxidants, and their antioxidant properties were comparable to those of a flavonoid extracted from haw­ thorn. The antioxidant effectiveness of the ten-carbon alkyl chain compound was comparable with that of the known antioxidant 3,5-di-t-butyl-4-hydroxytoluene (BHT). The least effective antioxidant studied proved to be the eight-carbon alkyl chain compound. The effect of these compounds on fluidity of the erythrocyte membrane has been studied, and for all an increase of fluidity of the membrane was observed. The changes in erythrocyte ghosts fluidity de­ pended both on concentration and type of compound. A fluorimetric study also indicated that rigidity of the erythrocyte membrane increased with degree of its oxidation, but with antioxidants present membrane rigidity increased less. 
  Reference    Z. Naturforsch. 53c, 425—430 (1998); received January 26/March 16 1998 
  Published    1998 
  Keywords    Antioxidants, Lipid Oxidation, Erythrocyte Ghost, Quaternary Ammonium Salts, Plant Flavonoid 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0425.pdf 
 Identifier    ZNC-1998-53c-0425 
 Volume    53 
2Author    Halina Kleszczyńska3, MałgorzataO. Święcimskab, Janusz Sarapuk3, Stanisław Witekb, Stanisław Przestalski3Requires cookie*
 Title    Protective Effect of Quaternary Piperidinium Salts on Lipid Oxidation in the Erythrocyte Membrane  
 Abstract    A new series of amphiphilic compounds with incorporated antioxidant functional group has been investigated. Piperidinium bromides, differing in the alkyl chain length (8, 10, 12, 14 and 16 carbon atoms in the chain) were synthesised to protect biological and/or model membranes against peroxidation and following negative consequences. Their antioxidant ac­ tivity was studied with erythrocytes subjected to UV radiation. The salts used inhibited lipid oxidation in the erythrocyte membrane. The degree of this inhibition depended on the alkyl chain length of the bromide used and increased with increasing alkyl chain length. A compar­ ison of the results obtained for piperidinium bromides with those obtained for the widely used antioxidant 3,5-di-r-butyl-4-hydroxytoluene (BH T) revealed that only two shortest alkyl chain salts were less efficient than BH T in protecting erythrocyte membranes. A similar comparison with antioxidant efficiency of flavonoids extracted from Rosa rugosa showed that they protected the membranes studied more weakly than the least effective eight-carbon alkyl chain piperidinium bromide. The three compounds of longest alkyl chains were the most active antioxidants. Their activities did not differ significantly. 
  Reference    Z. Naturforsch. 54c, 424 (1999); received January 22/February 24 1999 
  Published    1999 
  Keywords    Antioxidants, Lipid Oxidation, Erythrocyte Membrane, Quaternary Piperidinium Salts, Flavonoids 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0424.pdf 
 Identifier    ZNC-1999-54c-0424 
 Volume    54