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1981 (1)
1979 (2)
1Author    Wolfgang Lohmann, Rainer LangeRequires cookie*
 Title    On the Possible Involvement of Ascorbic Acid and Copper Proteins in Leukemia. III. ESR Investigations on the Interaction between Ascorbic Acid and Some Transition Metal Ions  
 Abstract    The interaction between lyophilized samples of ascorbic acid and Cu2+, Fe3+ or M n2+ has been investigated by means of ESR spectroscopy. All of the three transition metal ions form complexes with vitamin C, but only in the case of C u2+ and Fe3+ the interaction results in a reduction of the metal ions. C u2+ and ascorbic acid seem to form 2 : 1 complexes with an equilibrium constant of about K = 1 x 107 mol-1. None of these metal ion complexes exhibits, however, the ESR spectrum obtained with leukemic blood. 
  Reference    Z. Naturforsch. 34c, 546—549 (1979); received March 21/May 4 1979 
  Published    1979 
  Keywords    Leukemia, ESR, Ascorbic Acid, Transition Metal Ions 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0546.pdf 
 Identifier    ZNC-1979-34c-0546 
 Volume    34 
2Author    Wolfgang Lohmann, Jörg Schreiber, Walter Greulich, LeukemiaRequires cookie*
 Title    On the Possible Involvement of Ascorbic Acid and Copper Proteins in  
 Abstract    The interaction between lyophilized samples of ascorbic acid and some copper proteins (ceru-loplasmin, cytochrome-c-oxidase, ascorbate-oxidase) has been investigated by means of ESR spec­ troscopy. The spectra obtained are identical to the one obtained with leukemic blood. The conse­ quences of this for the molecular events occuring in cancer are discussed. The model proposed can explain the experimental findings reported thus far (such as change in spin concentration with the development of cancer, the presence of a high concentration of antioxidants etc.) as well as recon-sile the two existing and seemingly contradictory hypothesis. Possible implications for lipid per­ oxidation and for the respiratory process are discussed. 
  Reference    Z. Naturforsch. 34c, 550—554 (1979); received March 21/May 4 1979 
  Published    1979 
  Keywords    Leukemia, ESR, Ascorbic Acid, Copper Proteins, Lipid Peroxidation 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0550.pdf 
 Identifier    ZNC-1979-34c-0550 
 Volume    34 
3Author    Wolfgang LohmRequires cookie*
 Title    Ascorbate Oxidase and Its Possible Involvement in Cancer  
 Abstract    The electron spin resonance (ESR) spectrum of erythrocytes of a healthy male volunteer exhibited 2 min after intravenous administration of 1 g of ascorbic acid a considerable increase in spin concentration and a new signal at about g = 2.005 which we previously had found to correlate to the semidehydroascorbate (SDA) radical and which is not identical with the O j radical. Moreover, the vitamin C concentration in erythrocytes and plasma was considerably higher than in comparable samples of other volunteers treated identically. In the latter cases, the ESR spectrum of the erythrocytes was not modified at all. These findings suggest that there must be a substance which reacts with ascorbic acid specifically. It can be assumed that the enzyme ascorbate oxidase plays this decisive role in the ascorbic acid metabolism. For this reason, different amounts of ascorbate oxidase have been added to healthy erythrocytes treated in vitro with ascorbic acid and to tissue samples of lung cancer. As expected, the vitamin C effect as expressed by the appearance of the SDA signal and the increase in spin concentration could be reversed. It is suggested, therefore, that in special types of cancer, such as acute lymphatic leukemia and lung cancer, the concentration of ascorbate oxidase or of an enzyme acting like it is, primarily, diminished, while in other types it might be enlarged. 
  Reference    Z. Naturforsch. 36c, 804—808 (1981); received February 9/March 211981 
  Published    1981 
  Keywords    Ascorbic Acid, ESR, Copper Proteins, Leukemia, Lung Cancer 
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 TEI-XML for    default:Reihe_C/36/ZNC-1981-36c-0804.pdf 
 Identifier    ZNC-1981-36c-0804 
 Volume    36