| | 1 | Author
| Bernd Listab, A.Ndrea Golza, Wilhelm Bolandb, H. Artm, K. Lichtenthaler3 | Requires cookie* | | | Title
| Inhibition of de novo Fatty-Acid Biosynthesis in Isolated Chloroplasts by the Antibiotic Cerulenin and Its Synthetic Derivatives  | | | | Abstract
| The antibiotic cerulenin was shown to be a potent dose-dependent inhibitor o f de novo fatty-acid biosynthesis in intact isolated chloroplasts o f different plants (measured as [l4C]acetate incorporation into the total fatty-acid fraction). Various chemical derivatives o f cerulenin were synthesized and tested in the chloroplast assay-system o f oat, spinach and pea. M odifica tions o f the hydrocarbon chain o f cerulenin (e.g. tetrahydro-cerulenin and its short-chain c«-2,3-epoxy-4-oxoheptanam ide derivative) decreased the inhibitory activity o f cerulenin, whereas variations o f the epoxy-oxo-am ide structural element led to a com plete loss o f inhibi tion potency. The results indicate that the naturally occurring antibiotic cerulenin is the most active specific inhibitor o f de novo fatty-acid biosynthesis, but the form ation o f the hydroxy-lactam ring seems to be an essential requirement for the inhibitory activity. Those structural analogues o f cerulenin, which can no longer form a hydroxylactam ring, do not possess any inhibitory capacity. | | | |
Reference
| Z. Naturforsch. 47c, 382 (1992); received March 10 1992 | | | |
Published
| 1992 | | | |
Keywords
| Cerulenin, Cerulenin Derivatives, de novo Fatty Acid Biosynthesis, Isolated Chloroplasts | | | |
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| default:Reihe_C/47/ZNC-1992-47c-0382.pdf | | | | Identifier
| ZNC-1992-47c-0382 | | | | Volume
| 47 | |
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