Go toArchive
Browse byFacets
Bookbag ( 0 )
'Irritants' in keywords
Results  3 Items
Sorted by   
Section
Publication Year
1983 (1)
1982 (1)
1980 (1)
1Author    Bernd Sorg, Michael Gschwendt, HeinzWalter Thielmann, Erich HeckerRequires cookie*
 Title    Struktur-Wirkungsbeziehungen polyfunktioneller Diterpene des Tigliantyps, IV [1-3] Structure-Activity Relationships of Polyfunctional Diterpenes of the Tigliane Type, IV [1-3] Derivatives of Tigliane without or with Opened Cyclopropane Ring and their Irritant and Promoting Activity  
 Abstract    Derivate des Tiglians mit fehlendem oder geöffnetem Cyclopropanring und ihre irritierende und tumorpromovierende Wirkung The synthesis of the esters 6d-8d, 9 c and 10 c is described. These compounds are closely structurally related to the irritant and tumorpromoting 12-0-tetradecanoylphorbol-13-acetate (TPA, 2 a) and to phorbol-12,13-didecanoate (PDD, 2 c) except that they possess no cyclopropane ring. Biological tests show that opening or complete removal of the cyclopropane ring leads to nearly total loss of irritant or tumorpromoting (tested in the case of 9 c and 10 c) activity. 
  Reference    Z. Naturforsch. 35b, 1470—1475 (1980); eingegangen am 2. Juni 1980 
  Published    1980 
  Keywords    Cocarcinogens, Phorbol, Structure-activity-relationship, Tumor Promoter, Irritants 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_B/35/ZNB-1980-35b-1470.pdf 
 Identifier    ZNB-1980-35b-1470 
 Volume    35 
2Author    Bernd Sorg, Erich HeckerRequires cookie*
 Title    Zur Chemie des Ingenols, II [1] Ester des Ingenols und des A 18 -Isoingenols On the Chemistry of Ingenol, II [1] Esters of Ingenol and Zl 7 -8 -Isoingenol  
  Reference    Z. Naturforsch. 37b, 748—756 (1982); eingegangen am 3. Februar 1982 
  Published    1982 
  Keywords    Cocarcinogens, Ingenol, Initiation-Promoter, Irritants, Diterpene Esters 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-0748.pdf 
 Identifier    ZNB-1982-37b-0748 
 Volume    37 
3Author    A. Marston, E. HeckerRequires cookie*
 Title    Structure-Activity Relationships of Polyfunctional Diterpenes of the Tigliane Type, V* Preparation and Irritant Activities of Amino Acid and Peptide Esters of Phorbol  
 Abstract    The synthesis of a series of 12-O-amino acyl-and 12-0-peptidyl-13-acetate and -13,20-diacetate esters of the tetracyclic diterpene alcohol phorbol is described. These esters, which include amino acid moieties with both N-protected and free amino functions, were all tested for irritant activity on mouse ear. The highest activities were observed for esters with N-9-fluorenylmethyloxycarbonyl-protected leucine and 11-aminoundecanoic acid. 
  Reference    Z. Naturforsch. 38b, 1015—1021 (1983); received March 28 1983 
  Published    1983 
  Keywords    Amino Acids, Peptides, Phorbol Esters, Irritants, Tumour Promoters 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1015.pdf 
 Identifier    ZNB-1983-38b-1015 
 Volume    38