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1983 (2)
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1974 (2)
1Author    Anders Ljungqvist, Karl FolkersRequires cookie*
 Title    Study of Hydrogenolytic Cleavage of Peptide-Resin Benzyl Ester Bonds for Synthesis of Protected Fragments of the Human Leukocyte Interferon  
 Abstract    Three Boc-protected fragments of the human leukocyte interferon, LeIFA, have been synthesized: I, BOC LeIFA (99-105) (BOC-Val-Ile-Gln-Gly-Val-Gly-Val); II, BOC LeIFA (116-119) (BOC-Ile-Leu-Ala-Val); III, BOC LeIFA (123-126) (BOC-Phe-Gln-Arg(Tos)-Ile). The presence of the Boc-group was desired so that these peptides could serve as intermediates in fragment condensation toward larger segments of interferon. To achieve these intermediates, a study was desirable on three methods of cleavage of the benzyl ester-polymer bonds. It was found that hydrogenolysis with hydrogen and palla-dium generated in situ was distinctly superior to transfer hydrogenation with ammonium formate or cyclohexene. An effective swelling of the peptide-resin to allow penetration of palladium acetate into the matrix and mobility of the peptide chains on the resin to expose the benzyl ester bond to hydrogenolysis appear to be essential conditions for the best cleavage. 
  Reference    Z. Naturforsch. 38b, 1022—1024 (1983); received May 2 1983 
  Published    1983 
  Keywords    Interferon, Peptide Synthesis, Hydrogenation, Palladium Black, Conformation 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1022.pdf 
 Identifier    ZNB-1983-38b-1022 
 Volume    38 
2Author    M. Suh, G. Bodo, W. Wolf, G. Viehhauser, C. JungwirthRequires cookie*
 Title    Interferon Effect on Cellular Functions: Enhancement of Virus Induced Inhibition of Host Cell Protein Synthesis in Interferon-Treated Cells  
 Abstract    H errn P rofessor Dr. Otto Hoffmann-Ostenhof zum 60. G eburtstag gew idm et Total protein synthesis in mouse cells but not in confluent chick embryo fibroblasts (CEF) is inhibited shortly after infection with vaccinia virus. This inhibition by the infecting virus is enhanced drastically if the mouse cells have been pretreated with homologous interferon pre­ parations. The enhanced reduction of protein synthesis also occurs if the cells are treated with actinomycin D and is therefore to a large extent caused by an enhanced inhibition of amino acid incorporation into host cell proteins. Enhanced inhibition of total protein synthesis during the early stages of infection may be a prerequisite for the complete degeneration of the cells (lysis) which occurs later. Various alterations of mouse cells and chick embryo fibroblasts due to exposure to homologous interferon preparations are discussed with respect to the antiviral state induced in these cells. 
  Reference    (Z. Naturforsch. 29c, 623 [1974]; received April 23/May 31 1974) 
  Published    1974 
  Keywords    Interferon, Host Cell Functions, Proteinsynthesis, Poxvirus, Mouse Cells 
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 TEI-XML for    default:Reihe_C/29/ZNC-1974-29c-0623.pdf 
 Identifier    ZNC-1974-29c-0623 
 Volume    29 
3Author    Anders Ljungqvist, Karl Folkers+Requires cookie*
 Title    Synthesis of a Combined Fragment of Interferon, AeHuIFN a A(30-43)-(123-137)-NH2 Interferon May not be a Sychnologieal Peptide * AeHuIFN a A( 30-43)-( 123-137)-NH2, Ac-Leu-Lys-Asp-Arg-His-Asp-Phe-Gly-Phe- Pro-Gln-Glu-Glu-Phe-Phe-Gln-Arg-Ile-Thr-Leu-Tyr-Leu-Lys-Glu-Lys-Lys-Tyr-Ser- Pro-NH2 was  
 Abstract    synthesized toward encompassing the "active site" of the interferons. The design of this 29-amino acid peptide was based on considerations of homology between the different interferons and on combining two regions of interferons, and on known and predicted structural features. The peptide was characterized by amino acid analysis, thin layer chromatography in several systems, and by HPLC. As tested, the peptide neither showed antiviral activity nor blocked antiviral activity of interferon, indicating that the active site was not encompassed or that interferon may not be a sychnologieal peptide. 
  Reference    Z. Naturforsch. 38b, 1249—1252 (1983); received June 24 1983 
  Published    1983 
  Keywords    Interferon, Peptide Synthesis, Antiviral Activity, Synthetic Fragment, Active Site 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1249.pdf 
 Identifier    ZNB-1983-38b-1249 
 Volume    38 
4Author    Joachim Hilfenhaus, HermannE. KargesRequires cookie*
 Title    Growth Inhibition of Human Lymphoblastoid Cells by Interferon Preparations, Obtained from Human Leukocytes  
 Abstract    The growth inhibition of human lymphoblastoid cells by human interferon preparations (HIF) and a mock-interferon preparation (Mock-IF) was studied. HIF was induced in suspensions of primary human leukocytes by Newcastle Disease Virus. Mock-IF was prepared from uninduced cell suspension of a comparable batch. The highest degree of inhibition of cell propagation was ob­ tained on the EBV producer line P3HR1, the inhibition of the cell lines Raji and SKL 1 was significantly lower, no effect was observed on the cell line RPMI 1788 originating from a healthy donor. Mock-IF also caused a growth inhibition but to a lower degree as HIF. HIF and Mock-IF are similar in the following properties: 1. Stability at pH 2 at 4 °C for four days, 2. sensitivity to tryptic digestion, and 3. molecular weights in the range between 5,000 and 40,000 daltons. 
  Reference    (Z. Naturforsch. 29c, 618 [1974]; received May 13/July 11 1974) 
  Published    1974 
  Keywords    Interferon, Mock-Interferon, Growth Inhibition, Human Lymphoblastoid Cells, Epstein Barr Virus 
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 TEI-XML for    default:Reihe_C/29/ZNC-1974-29c-0618.pdf 
 Identifier    ZNC-1974-29c-0618 
 Volume    29 
5Author    Wolfgang LohmannRequires cookie*
 Title    On a Possible Mechanism of Action of Interferon  
 Abstract    The effect o f interferon on the ESR spectra o f erythrocytes treated with ascorbic acid has been investigated. This model system has been chosen since it represents identically the spectra obtained in cases with acute lymphatic leukemia. The data obtained show that small interferon concentrations increase, while larger concentrations decrease the effect produced by ascorbic acid resulting, finally, in the original erythrocyte ESR spectrum. Atomic absorption studies reveal the presence of copper which might be part of the active principle. 
  Reference    Z. Naturforsch. 36c, 323—325 (1981); received November 18 1980 
  Published    1981 
  Keywords    Interferon, Cancer, Ascorbic Acid, Spin Concentration, Electron Spin Resonance Spectrum 
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 TEI-XML for    default:Reihe_C/36/ZNC-1981-36c-0323.pdf 
 Identifier    ZNC-1981-36c-0323 
 Volume    36