ZfN: Search Results

1	Author	M. Suh, G. Bodo, W. Wolf, G. Viehhauser, C. Jungwirth	Requires cookie*
	Title	Interferon Effect on Cellular Functions: Enhancement of Virus Induced Inhibition of Host Cell Protein Synthesis in Interferon-Treated Cells
	Abstract	H errn P rofessor Dr. Otto Hoffmann-Ostenhof zum 60. G eburtstag gew idm et Total protein synthesis in mouse cells but not in confluent chick embryo fibroblasts (CEF) is inhibited shortly after infection with vaccinia virus. This inhibition by the infecting virus is enhanced drastically if the mouse cells have been pretreated with homologous interferon pre parations. The enhanced reduction of protein synthesis also occurs if the cells are treated with actinomycin D and is therefore to a large extent caused by an enhanced inhibition of amino acid incorporation into host cell proteins. Enhanced inhibition of total protein synthesis during the early stages of infection may be a prerequisite for the complete degeneration of the cells (lysis) which occurs later. Various alterations of mouse cells and chick embryo fibroblasts due to exposure to homologous interferon preparations are discussed with respect to the antiviral state induced in these cells.
	Reference	(Z. Naturforsch. 29c, 623 [1974]; received April 23/May 31 1974)
	Published	1974
	Keywords	Interferon, Host Cell Functions, Proteinsynthesis, Poxvirus, Mouse Cells
	Similar Items	Find
	DEBUG INFO
	TEI-XML for	default:Reihe_C/29/ZNC-1974-29c-0623.pdf
	Identifier	ZNC-1974-29c-0623
	Volume	29

2	Author	Joachim Hilfenhaus, HermannE. Karges	Requires cookie*
	Title	Growth Inhibition of Human Lymphoblastoid Cells by Interferon Preparations, Obtained from Human Leukocytes
	Abstract	The growth inhibition of human lymphoblastoid cells by human interferon preparations (HIF) and a mock-interferon preparation (Mock-IF) was studied. HIF was induced in suspensions of primary human leukocytes by Newcastle Disease Virus. Mock-IF was prepared from uninduced cell suspension of a comparable batch. The highest degree of inhibition of cell propagation was ob tained on the EBV producer line P3HR1, the inhibition of the cell lines Raji and SKL 1 was significantly lower, no effect was observed on the cell line RPMI 1788 originating from a healthy donor. Mock-IF also caused a growth inhibition but to a lower degree as HIF. HIF and Mock-IF are similar in the following properties: 1. Stability at pH 2 at 4 °C for four days, 2. sensitivity to tryptic digestion, and 3. molecular weights in the range between 5,000 and 40,000 daltons.
	Reference	(Z. Naturforsch. 29c, 618 [1974]; received May 13/July 11 1974)
	Published	1974
	Keywords	Interferon, Mock-Interferon, Growth Inhibition, Human Lymphoblastoid Cells, Epstein Barr Virus
	Similar Items	Find
	DEBUG INFO
	TEI-XML for	default:Reihe_C/29/ZNC-1974-29c-0618.pdf
	Identifier	ZNC-1974-29c-0618
	Volume	29

3	Author	Wolfgang Lohmann	Requires cookie*
	Title	On a Possible Mechanism of Action of Interferon
	Abstract	The effect o f interferon on the ESR spectra o f erythrocytes treated with ascorbic acid has been investigated. This model system has been chosen since it represents identically the spectra obtained in cases with acute lymphatic leukemia. The data obtained show that small interferon concentrations increase, while larger concentrations decrease the effect produced by ascorbic acid resulting, finally, in the original erythrocyte ESR spectrum. Atomic absorption studies reveal the presence of copper which might be part of the active principle.
	Reference	Z. Naturforsch. 36c, 323—325 (1981); received November 18 1980
	Published	1981
	Keywords	Interferon, Cancer, Ascorbic Acid, Spin Concentration, Electron Spin Resonance Spectrum
	Similar Items	Find
	DEBUG INFO
	TEI-XML for	default:Reihe_C/36/ZNC-1981-36c-0323.pdf
	Identifier	ZNC-1981-36c-0323
	Volume	36