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'Indole Alkaloids' in keywords Facet   section ZfN Section B  [X]
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1983 (1)
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1Author    H.E JRequires cookie*
 Title    Synthetic Studies towards Vinblastine and its Analogues, VI The Markownikov Addition of Acetic Acid to Catharanthine by a Modification of the Prevost Reaction ATTA-UR-RAHMAN, NIGHAT WAHEED, and MARYAM GHAZALA  
 Abstract    The reaction of catharanthine under modified prevost reaction conditions has afforded 20-acetoxydihydrocatharanthine, an important intermediate for the synthesis of anti-leukaemic alkaloids, vinblastine and vincristine. 
  Reference    (Z. Naturforsch. 31b, 264—266 [1976]; received September 4 1975) 
  Published    1976 
  Keywords    Vinblastine, Anti-cancer Drugs, Indole Alkaloids, Prevost Reaction 
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 TEI-XML for    default:Reihe_B/31/ZNB-1976-31b-0264.pdf 
 Identifier    ZNB-1976-31b-0264 
 Volume    31 
2Author    H.E JRequires cookie*
 Title    Reduction of Indolic Imides with Sodium Borohydride ATTA-UR-RAHMAN and NIGHAT WAHEED  
 Abstract    Reduction The reduction of imides with sodium boro-hydride affords ring cleaved products instead of the corresponding carbinol lactams sug-gested previously. 
  Reference    (Z. Naturforsch. 31b, 287—288 [1976]; received September 23 1975) 
  Published    1976 
  Keywords    Imides, Cyclization, Indole Alkaloids, Sodium Borohydride 
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 TEI-XML for    default:Reihe_B/31/ZNB-1976-31b-0287_n.pdf 
 Identifier    ZNB-1976-31b-0287_n 
 Volume    31 
3Author    W. N. Speckamp, J. Dijkink, P. Pasman, J. C. HubertRequires cookie*
 Title    Indole [3,2 gjindolizidines via Sodium Borohydride Reduction of Indolic Imides  
 Abstract    Acid-controlled sodium borohydride reduc-tion of imides followed by cyclisation of the carbinol lactams formed affords the title compounds in good yields. 
  Reference    (Z. Naturforsch. 33b, 127—128 [1978]; received September 12 1977) 
  Published    1978 
  Keywords    Reduction, Imides, Cyclisation, Carbinol Lactam, Indole Alkaloids 
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 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0127_n.pdf 
 Identifier    ZNB-1978-33b-0127_n 
 Volume    33 
4Author    Atta-Ur-Rahman, Sadiqa Firdous, Anwer BashaRequires cookie*
 Title    Alkaloids, IX* Some Aspects of the Chemistry of C atliar anthine  
 Abstract    Vinblastine and Vincristine are binary indole-indoline alkaloids occurring in traces in the leaves of Vinca rosea. They are among the most powerful chemotherapeutic agents available to man for the treatment of a variety of cancers. Their high cost and complexity of structure has attracted the attention of many eminent chemists towards their synthesis. The first synthesis of both these anta'-tumour alkaloids was reported by us last year [7] starting from two major alkaloids, catharanthine and vindo-line, which co-occur in the same plant. Some aspects of the chemistry of catharanthine are now presented including a novel one-step de-carbomethoxylation reaction with H2S in glacial acetic acid and a reversible isomerization of catharanthine with sodium borohydride. A study of the life-time of catharanthine in hot glacial acetic acid substantiates the earlier work of the Anglo-French group on the biosynthesis of indole alkaloids. 
  Reference    Z. Naturforsch. 33b, 469—470 (1978); received December 5 1977 
  Published    1978 
  Keywords    Vinblastine, Vincristine, Decarbomethoxylation, anti-Cancer Drugs, Indole Alkaloids 
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 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0469_n.pdf 
 Identifier    ZNB-1978-33b-0469_n 
 Volume    33 
5Author    Werner Kohl, Barbara Witte, Gerhard HöfleRequires cookie*
 Title    Alkaloide aus Catharanthus roseus-Zellkulturen, II [1] Alkaloids from Catharanthus roseus Tissue Cultures, II [1]  
 Abstract    From the extract of Catharanthus roseus tissue cultures 16 different indole alkaloids have been isolated belonging to heteroyohimbane, aspidosperma and iboga types. The structures were deduced by UV, NMR and mass spectrometry. Ajmalicine (1) and catharanthine (16) were found to be the major constituents, tetra-hydroalstonine (2), akuammigine (3), 3-isoajmalicine (4), pleiocarpamine (6), akuammiline (6), tabersonine (7), 20-hydroxytabersonine (8), lochnericine (9), horhammericine (10), minovincinine (11), vindolinine (12), 20-epivindolinine (18), vindolinine -Nt -oxide (14) and 20-epivindolinine-Nb-oxide (16) could be determined as minor or trace alkaloids. 
  Reference    Z. Naturforsch. 36b, 1153—1162 (1981); eingegangen am 20. Mai 1981 
  Published    1981 
  Keywords    Indole Alkaloids, Catharanthus roseus, Cell Cultures 
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 TEI-XML for    default:Reihe_B/36/ZNB-1981-36b-1153.pdf 
 Identifier    ZNB-1981-36b-1153 
 Volume    36 
6Author    Werner Kohl, Barbara Witte, Gerhard HöfleRequires cookie*
 Title    Alkaloide aus Catharanthus roseus-Zellkulturen, III [1] Alkaloids from Catharanthus roseus Tissue Cultures, III [1]  
 Abstract    From the methanol extract of Catharanthus roseus tissue cultures sitsirikine (2), isositsirikine (3), dihydrositsirikine (4), yohimbine (5), 3-iso-19-epiajmalicine (6), pleio-carpamine (7), antirhin (8) and two up to now unknown alkaloids have been isolated in addition to the compounds previously found in the hexane extract. The structures belonging to lieteroyohimbane, vallesiachotamine, corynanthe and related types were deduced by UV, NMR and mass spectroscopy. 
  Reference    Z. Naturforsch. 37b, 1346—1351 (1982); eingegangen am 17. Mai 1982 
  Published    1982 
  Keywords    Indole Alkaloids, Catharanthus roseus, Cell Cultures 
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 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-1346.pdf 
 Identifier    ZNB-1982-37b-1346 
 Volume    37 
7Author    Atta-Ur-Rahman, Maryam Ghazala, H.E JRequires cookie*
 Title    The Synthesis of 11-Methoxynauclefine and 11-Methoxyrutaecarpine  
 Abstract    The synthesis of 11 -methoxynauclefine and 11 -methoxyrutaecarpine is described starting from harmaline. Harmaline (1) and harmine (20) are major indole alkaloids in the seeds of Pegcinum harmala [1-3]. The demonstration of a highly mobile equilibrium between the imine and enamine tautomers of harma-line by deuteration studies [4] had led us previously to report the synthesis of a number of novel indolo-quinolizidines [5, 6], reserpine and sempervirine analogues [7, 8] and gambirtannine derivatives [9] utilizing the enamine chemistry of harmaline and its derivatives. 
  Reference    Z. Naturforsch. 37b, 762—771 (1982); received November 11 1981 
  Published    1982 
  Keywords    Nauclefine, Rutaecarpine, Indole Alkaloids, a>i<i-Tumour Agents 
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 TEI-XML for    default:Reihe_B/37/ZNB-1982-37b-0762.pdf 
 Identifier    ZNB-1982-37b-0762 
 Volume    37 
8Author    Jürgen Schallenberg, Eckart MeyerRequires cookie*
 Title    Simple Syntheses of 3-Substituted Indoles and their Application for High Yield 14 C-Labelling  
 Abstract    Methods are described which allow the synthesis of several plant indole alkaloids and their metabolites at different scales. Compounds synthesized include gramine (1) (3-di-methylaminomethylindole) which is directly derived from indole, while its biosynthetic precursors 3-aminomethylindole (3) and 3-methylaminomethylindole (2) as well as indole-3-carboxylic acid (7) are synthesized via indole-3-aldehyde (6). Slight changes of the experimental conditions allow syntheses with high yields not only at the molar but also at the /imolar level. This is extremely useful when isotope labelled compounds of high specific radioactivity are required for studies of plant metabolism. 
  Reference    (Z. Naturforsch. 38b, 108—112 [1983]; received July 22 1982) 
  Published    1983 
  Keywords    3-Substituted Indoles, Indole Alkaloids, UV Spectra, MS Spectra, 1 H NMR spectra 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-0108.pdf 
 Identifier    ZNB-1983-38b-0108 
 Volume    38