ZfN: Search Results

1	Author	Gabriele Luckner, Paul Renz	Requires cookie*
	Title	On the Phospholipase Activity in Bovine Seminal Vesicles and Its Possible Role in the Regulation of the Prostaglandin Biosynthesis
	Abstract	A phospholipid mixture was isolated from bovine seminal vesicle tissue. This phospholipid pre paration contained the following prostaglandin precursor fatty acids: 4.7 percent 5,8,11-eicosa-trienoic acid, 9.1 percent 5,8,11,14-eicosatetraenoic acid and 0.9 percent 5,8,11,14,17-eicosa-pentaenoic acid. With this phospholipid preparation as substrate phospholipase activity could be detected in different fractions of bovine seminal vesicle cells. The highest phospholipase activity was found in the microsomal fraction, less in the mitochondria and essentially no activity in the cytosol. With a microsome preparation (acetone powder) of bovine seminal vesicles the influence of certain effectors on the phospholipase activity was investigated. Prostaglandins E2 and F2a (10 5 m) showed 19 and 41 percent inhibition, DB-c-AMP (2 x 10—9 m) 54 percent, c-AMP (1 0 ~ 9 m) 22 percent, epinephrine (10—4 m) 60 percent, testosterone (10—5 m) 25 percent inhibition of the phos pholipase activity. Whereas ethanol exhibits also a strong inhibition on the phospholipase activity, it shows a pronounced activation of the prostaglandin synthetase.
	Reference	(Z. Naturforsch. 30c, 429 [1975]; received March 25 1975)
	Published	1975
	Keywords	Phospholipases, Phospholipids, Bovine Seminal Vesicles, Prostaglandins, Hormones
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	TEI-XML for	default:Reihe_C/30/ZNC-1975-30c-0429.pdf
	Identifier	ZNC-1975-30c-0429
	Volume	30

2	Author	Michael Entzeroth, Lothar Jaenicke	Requires cookie*
	Title	Blepharisma japonicum Synthesis of Blepharismone, the Low-Molecular Conjugation Hormone of Blepharisma japonicum
	Abstract	An effective and versatile synthesis of 5-hydroxytrypto-phane derivatives offers good access to the conjugation in ducing hormone blepharismone o f the ciliate Blepharisma japonicum and to derivatives and analogues of this biolog ically active compound. 5'-Fluoroblepharismone and 2'-des-formamidoblepharismone induce conjugation at 500 and 1200 times, respectively, the concentration of the true effector. At high concentration, however, the 2'-des-form-amido derivative desensitizes the receptor system for the natural gamone.
	Reference	Z. Naturforsch. 36c, 180 (1981); eingegangen am 20. Oktober 1980
	Published	1981
	Keywords	Blepharisma japonicum, Blepharismone, Conjugation, Gamones, Hormones
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	TEI-XML for	default:Reihe_C/36/ZNC-1981-36c-0180_n.pdf
	Identifier	ZNC-1981-36c-0180_n
	Volume	36

3	Author	Michael Entzeroth, Lothar Jaenicke	Requires cookie*
	Title	von Blepharisma japonicum Structure-Activity-Relation of Analogues and Homologues of Blepharismone, the Low-M olecular Conjugation Hormone of Blepharisma japonicum
	Abstract	Some functional derivatives o f blepharismone, the low-m olecular conjugation hormone o f Blepharisma japonicum, were synthesised and tested for their biological activity. The lipophilicity constant o f the substituent in 5-position o f the aromatic system directly correlates with the conjugation-inducing effect o f this substance. Any change in the N -form yl-position leads to com pounds less active than blepharismone, non-active or even inhibitory. Blepharismone-related kynurenine derivatives are inhibitors o f the gamone activity depending on structural relationship.
	Reference	Z. Naturforsch. 37c, 1136—1140 (1982); received August 2/Septem ber 20 1982
	Published	1982
	Keywords	Blepharisma japonicu m, Blepharismone, Conjugation, Hormones, Receptors
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	TEI-XML for	default:Reihe_C/37/ZNC-1982-37c-1136.pdf
	Identifier	ZNC-1982-37c-1136
	Volume	37