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1985 (1)
1983 (1)
1974 (1)
1Author    Requires cookie*
 Title    Synthese eines Peptids m it vermutlicher W irkung des W achstum shorm on-freisetzenden Hormons (G H -R H ) A new synthesis for the tripeptide Pyr- Ser-Gly-NH2, with mutual GH-RH activity is described. Z-L-Pyr-OH is reacted with HO- NSu to the protected amino acid derivative Z-L-Pyr-ONSu. Further intermediates in the synthesis are Z-L-Pyr-L-Ser(Bzl)-OH and Z-L-Pyr-L-Ser(Bzl)-Gly-NHa  
 Abstract    Synthesis of a P eptide w ith Suggested A ctivity of G row th H orm one-R eleasing H orm one (GH-RH) K a r l Z e c h u n d W o l f g a n g V o e l t e r Peptide 
  Reference    (Z. Naturforsch. 29b, 818—819 [1974]; eingegangen am 9. Oktober 1974) 
  Published    1974 
  Keywords    hormones, Hypothalamus-releasing hormones, Peptide synthesis 
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 TEI-XML for    default:Reihe_B/29/ZNB-1974-29b-0818_n.pdf 
 Identifier    ZNB-1974-29b-0818_n 
 Volume    29 
2Author    Karl Folkers, CyrilY. Bowers, Teresa Kubiak, Janusz StepinskiRequires cookie*
 Title    Synthesis and Antiovulatory Activities in Rats of Analogs of the Luteinizing Hormone Releasing Hormone Having a Moiety of /?-(3-Quinolyl)-D-a-alanine in Positions 3 and 6  
 Abstract    Analogs of the luteinizing hormone releasing hormone (LHRH) having a moiety (D-Qal-) of/3-(3-quinolyl)-D-a-alanine were synthesized toward more effective inhibitors of ovulation. [N-Ac-^Cl-D-Phe 1 -2 , D-3-Pal 3 , D-3-Qal 6 , D-Ala 10 ]-LHRH was the most effective, and had an antiovulatory activity of 40% at 1 /ig/rat. D-3-Qal 6 was as effective as D-Trp 6 in combination with N-Ac-3 z1 Pro 1 , ^oF-D-Phe 2 , D-Trp 3 . D-Arg 6 was superior to D-3-Qal 6) in combination with N-Ac-^Cl-D-Phe 1 ' 2 , D-Trp 3 (or D-3-Pal 3), D-Ala 10 . The introduction of D-3-Qal 3 , D-His 3 and D-Arg 3 in comparable analogs caused sub-stantial loss of activities. Abbreviations D-3-Pal = /S-(3-pyridyl)-D-a-alanine; D-3-Qal = ß-(3-quinolyl)-D-a-alanine; BOC = fertf-butyloxy-carbonyl; ÄOC = tferf-amyloxycarbonyl; DCC = N,N'-dicyclohexylcarbodiimide; 3 ZlPro = 3,4-dehydro-L-proline; pF-D-Phe — yara-fluoro-D-phenylalanine; ^Cl-D-Phe = ^»am-ehloro-D-phenylalanine; Ac = acetyl, HPLC = high performance liquid chromato-graphy. 
  Reference    Z. Naturforsch. 38b, 1253—1256 (1983); received June 27 1983 
  Published    1983 
  Keywords    Ovulation, Hormone, Antagonist, Quinolylalanine, Luteinizing Hormone Releasing Hormone 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-1253.pdf 
 Identifier    ZNB-1983-38b-1253 
 Volume    38 
3Author    Karl Folkers, CyrilY. Bowers, Yin-Zeng Liu, Xiao Shao-Bo, Hong-Ming Shieh, Chu Ji-YuRequires cookie*
 Title    Antagonists of the Luteinizing Hormone Releasing Hormone with Emphasis on Amino Acids in Position Five  
 Abstract    Seventeen analogs of the luteinizing hormone releasing hormone (LHRH) have been syn-thesized, bioassayed, and compared for antiovulatory activity (AOA) in rats. The emphasis of design was replacement of Tyr 5 of LHRH. Position 5 has not been extensively studied. [N—Ac—D-2-Nal 1 , D-pClPhe 2 , D-3-Pal 3 , D-Arg 6 , D—Ala 10 ]-LHRH was the baseline for new designs. Comparison of the AOA's of the 17 analogs with the baseline revealed the two peptides with Phe 5 and 3-Pal 5 had equivalent AOA's, and were the best of the 17, and about 45% more potent than the baseline. Analogs with pClPhe 5 , oClPhe 5 , a-MepClPhe 5 , 2-Nal 5 , Trp 5 , and His 5 were less potent than the Phe 5 -and 3-Pal 5 -analogs. Based on the Phe 5 -analog, eight other analogs were synthesized with changes in positions 1, 2, 3 and 7 and although none were better than the baseline, 5/8 showed 20—60% AOA's at 250 ng and revealed optimum positions for new designs. 
  Reference    Z. Naturforsch. 40b, 313—316 (1985); received August 20 1984 
  Published    1985 
  Keywords    Peptide, Hormone, Ovulation, Luteinizing Hormone Releasing Hormone, Antagonist 
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 TEI-XML for    default:Reihe_B/40/ZNB-1985-40b-0313.pdf 
 Identifier    ZNB-1985-40b-0313 
 Volume    40