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'Hemolysis' in keywords Facet   section ZfN Section C:Volume 054  [X]
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1999 (1)
1Author    Janusz Sarapuk3, Halina Kleszczyriska3, JuliuszJoanna Pernakb, Bozenna Kalewskab, Rözycka-Roszak3Requires cookie*
 Title    Influence of Counterions on the Interaction of Pyridinium Salts with Model Membranes  
 Abstract    The interaction of pyridinium salts (PS) with red blood cells and planar lipid membranes was studied. The aim of the work was to find whether certain cationic surfactant counterion influence its possible biological activity. The counterions studied were C L , Br", I-, C 104~, BF4~ and N 0 3_. The model membranes used were erythrocyte and planar lipid membranes (BLM). At high concentration the salts caused 100% erythrocyte hemolysis (C 10o) or broke BLMs (CC). Both parameters describe mechanical properties of model membranes. It was found that the efficiency of the surfactant to destabilize model membranes depended to som e degree on its counterion. In both, erythrocyte and BLM experiments, the highest efficiency was observed for Br_, the lowest for N 0 3_. The influence o f all other anions on surfactant efficiency changed between these two extremities; that of chloride and perchlorate ions was similar. Some differences were found in the case o f BF4~ ion. Its influence on hemolytic possibilities of PS was significant while BLM destruction required relatively high concentration of this anion. Apparently, the influence of various anions on the destructive action of PS on the model membrane used may be attributed to different mobilities and radii o f hydrated ions and hence, to different possibilities o f particular anions to modify the surface potential of model membranes. This can lead to a differentiated interaction o f PS with m odi­ fied bilayers. Moreover, the effect of anions on the water structure must be taken into ac­ count. It is important whether the anions can be classified as water ordering kosm otropes that hold the first hydration shell tightly or water disordering chaotropes that hold water m olecules in that shell loosely. 
  Reference    Z. Naturforsch. 54c, 952 (1999); received April 6/May 20 1999 
  Published    1999 
  Keywords    M odel Membranes, Hemolysis, Stability, Cationic Surfactants, Counterions 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0952.pdf 
 Identifier    ZNC-1999-54c-0952 
 Volume    54