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1986 (1)
1Author    Reinhold Tacke3, A. Nke Bentlage-Felten, H. Aryanto, Linoha, StephenM. AgdabRequires cookie*
 Title    Sila-Pharmaka, 34. Mitt. [1] Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften  
 Abstract    Starting from tetram ethoxysilane, sila-triparanol 4b and sila-ethamoxytriphetol 8b were synthesized by four-step syntheses. 4b and 8b exhibit a strong hypolipidem ic activity in mice after p.o. administration. W hereas 4b and its carbon analogue triparanol (4a) show a similar hypolipidem ic potency, 8b was found to be less potent than its carbon analogue etham oxy­ triphetol (8a). The silicon com pounds 4b and 8b are less toxic (repeated administration over a period o f 8 days) than the corresponding carbon analogues 4a and 8a, respectively. 
  Reference    Z. Naturforsch. 41b, 649 (1986); eingegangen am 11. Novem ber 1985 
  Published    1986 
  Keywords    Sila-Substitution, Triparanol, Etham oxytriphetol, H ypolipidem ic Activity Toxicological Properties 
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 TEI-XML for    default:Reihe_B/41/ZNB-1986-41b-0649.pdf 
 Identifier    ZNB-1986-41b-0649 
 Volume    41