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1Author    C. Hristiane, T. Em Pête, M. Ichel Devys, M. Ichel BarbierRequires cookie*
 Title    Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues  
 Abstract    Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phy­ toalexins cyclobrassinin, brassilexin (previously isolated from vegetables o f the Cruciferae family) and their syn­ thetic analogues 5-methoxybrassilexin and hom ocyclo-brassinin. The most biologically active o f these products is brassilexin (L D 50 = 8 (ig/ml). 
  Reference    Z. Naturforsch. 46c, 706 (1991); received January 21 1991 
  Published    1991 
  Keywords    Growth Inhibition, Cancer Cells, Phytoalexins, Cruci­ fer ae 
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 TEI-XML for    default:Reihe_C/46/ZNC-1991-46c-0706_n.pdf 
 Identifier    ZNC-1991-46c-0706_n 
 Volume    46 
2Author    Joachim Hilfenhaus, HermannE. KargesRequires cookie*
 Title    Growth Inhibition of Human Lymphoblastoid Cells by Interferon Preparations, Obtained from Human Leukocytes  
 Abstract    The growth inhibition of human lymphoblastoid cells by human interferon preparations (HIF) and a mock-interferon preparation (Mock-IF) was studied. HIF was induced in suspensions of primary human leukocytes by Newcastle Disease Virus. Mock-IF was prepared from uninduced cell suspension of a comparable batch. The highest degree of inhibition of cell propagation was ob­ tained on the EBV producer line P3HR1, the inhibition of the cell lines Raji and SKL 1 was significantly lower, no effect was observed on the cell line RPMI 1788 originating from a healthy donor. Mock-IF also caused a growth inhibition but to a lower degree as HIF. HIF and Mock-IF are similar in the following properties: 1. Stability at pH 2 at 4 °C for four days, 2. sensitivity to tryptic digestion, and 3. molecular weights in the range between 5,000 and 40,000 daltons. 
  Reference    (Z. Naturforsch. 29c, 618 [1974]; received May 13/July 11 1974) 
  Published    1974 
  Keywords    Interferon, Mock-Interferon, Growth Inhibition, Human Lymphoblastoid Cells, Epstein Barr Virus 
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 TEI-XML for    default:Reihe_C/29/ZNC-1974-29c-0618.pdf 
 Identifier    ZNC-1974-29c-0618 
 Volume    29 
3Author    Jürgen Van Der Bosch, Heinz MaierRequires cookie*
 Title    Density-Dependent Growth Inhibiting Interactions between 3T3 and SV40-3T3 Cells in Mixed Cultures  
 Abstract    3T3 cells are shown to reduce SV40-3T3 cell population growth in a density-dependent manner in co-cultures of 3T3 and SV40-3T3 cells. The development of this inhibitory activity roughly parallels the development of density-dependent inhibition of growth in homogeneous 3T3 control cultures. The extent of reduction of SV40-3T3 growth can be manipulated by pretreatment of 3T3 cells with a high serum concentration. SV40-3T3 growth rates are reduced by factors between 10 and 20 under optimum inhibitory conditions as compared to SV40-3T3 growth in control cultures. 
  Reference    Z. Naturforsch. 34c, 272 (1979); received December 19 1978 
  Published    1979 
  Keywords    3T3 Cells, SV40-3T3 Cells, Growth Inhibition, Cell Interactions 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0272.pdf 
 Identifier    ZNC-1979-34c-0272 
 Volume    34 
4Author    M. WinkRequires cookie*
 Title    Chemical Defense of Leguminosae. Are Quinolizidine Alkaloids Part of the Antimicrobial Defense System of Lupins?  
 Abstract    Growth o f 6 bacteria (Serratia marcescens, Bacillus megaterium , Bacillus subtilis, Streptococcus viridis, Micrococcus luteus, and M ycobacterium ph lei) was inhibited by 50% if the growth m edium contained sparteine at concentrations between 0 .5 -1 0 m M . Total growth inhibition, which was bacteriostatic in nature, was achieved at 20 m M . The growth o f 6 phytopathogenic fungi was also affected: at a sparteine concentration o f 15 m M the growth o f Alternaria porri was reduced by 40% as compared to the untreated control. R espective values were 18% inhibition for Piricularia oryzae, 33% for H elminthosporium carbonum, 15% for R hizoctonia solani, 5% for Fusarium oxysporum, and 42% for Asperquillus oryzae. Since the concentrations o f quinolizidine alkaloids range from 1 -2 0 0 m M (roots, leaves, or stems) or 1 0 -2 0 0 m m ol/k g (seeds) in Legum inosae, it is discussed whether quinolizidine alkaloids are involved in the antim icrobial defense o f lupins, in addition to their potential role as allelopathic or herbivore repellent defense com pounds. 
  Reference    Z. Naturforsch. 39c, 548 (1984); received January 23 1984 
  Published    1984 
  Keywords    Quinolizidine Alkaloids, Growth Inhibition, Bacteria, Fungi, Antim icrobial Defense 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0548.pdf 
 Identifier    ZNC-1984-39c-0548 
 Volume    39 
5Author    W. Erner, K. Roll, StefanP. Ostius, F. Riedhelm, S. ChneiderRequires cookie*
 Title    Proliferation Kinetics and Metabolic Features of in vitro Grown Ehrlich Ascites Tumor Cells in the Presence of Exogenous Pyruvate  
 Abstract    The proliferation o f in vitro grown Ehrlich ascites tum or cells is inhibited by pyruvate concen­ trations > 2 m M . In the presence o f 4 —5 m M pyruvate the growth is reduced to about 50% , in the presence o f 20 mM to about 5 — 10%. Viability o f the cells is not severely affected. Increase o f D N A corresponds to the cell growth. On recultivation in pyruvate free standard m edium , growth is nearly normal. Flow cytometric analyses o f the proliferation kinetics of the cells in the presence o f 20 m M pyruvate revealed a retardation o f the passage o f all phases o f the cell cycle. N o phase specific effects could be detected though the S-and G 2M -p hase are more afflicted than G l . The growth inhibition o f E A T cells by pyruvate seem s to depend on the presence of glucose. Exogenous pyruvate (> 1 —2 m M) causes an activation o f pyruvate dehydrogenase, a reduction o f lactate production from glucose and a stimulation o f lipid biosynthesis; the N A D /N A D H ratio of the cells is reduced and a rise o f glycolytic interm ediates beyond glyceraldehyde-3-phosphate dehydrogenase is observed. Maximal activation of pyruvate dehydrogenase by non toxic concen­ trations o f dichloroacetate is also accom pagnied by an inhibition o f cell growth. It is suggested that an increase o f glyceraldehyde-3-phosphate level and the changes in the redox state o f the cells are o f relevance for the inhibition o f cell growth by pyruvate. 100—500 ^im exogenous glycer-aldehyde-3-phosphate strongly inhibited cell growth. 
  Reference    Z. Naturforsch. 41c, 787—794 (1986); received March 20 1986 
  Published    1986 
  Keywords    Ehrlich A scites Tumor Cells, Growth Inhibition, Pyruvate, M etabolism 
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 TEI-XML for    default:Reihe_C/41/ZNC-1986-41c-0787.pdf 
 Identifier    ZNC-1986-41c-0787 
 Volume    41