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1996 (1)
1Author    M. Nogues, A. Cuenda, F. H. Enao, C. Gutierrez-M, ErinoRequires cookie*
 Title    Ca2+ Uptake Coupled to Glycogen Phosphorolysis in the Glycogenolytic-Sarcoplasmic Reticulum Complex from Rat Skeletal Muscle  
 Abstract    The glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle accumulates C a2+ upon stimulation of glycogen phosphorolysis in the absence of added ATP. It is shown that an efficient C a2+ uptake involves the sequential action of glycogen phosphorylase, phos-phoglucomutase and hexokinase, which generate low concentrations of A TP (approximately 1 -2 ^m) compartm entalized in the immediate vicinity of the sarcoplasmic reticulum C a2+, Mg2+-ATPase (the C a2+ pump). The C a2+ uptake supported by glycogenolysis in this subcel-lular structure is strongly stimulated by micromolar concentrations of AMP, showing that the glycogen phosphorylase associated with this complex is in the dephosphorylated b form. The results point out that the flux through this compartmentalized metabolic pathway should be enhanced in physiological conditions leading to increased A M P concentrations in the sarcoplasm, such as long-lasting contractions and in ischemic muscle. 
  Reference    Z. Naturforsch. 51c, 591 (1996); received January 9/February 28 1996 
  Published    1996 
  Keywords    C a2 +-U ptake, Glycogenolysis, Sarcoplasmic Reticulum, Rat, Skeletal Muscle 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0591.pdf 
 Identifier    ZNC-1996-51c-0591 
 Volume    51