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1979 (1)
1Author    ArminH. Ildebrandt, Rudolf Mengel, HelmutW. SauerRequires cookie*
 Title    Characterization of an Endogenous Transcription Inhibitor from Physarum polycephalum  
 Abstract    A substance has been purified from isolated nuclei of Physarum polycephalum by equilibrium and velocity gradient centrifugations, ion exchange chromatography and gel filtration which has a high molecular weight, can be labeled in vivo with 32P, is heat stable and resistant to amylases, proteases, nucleases and phosphodiesterase but is sensitive to phosphatases or hydrolysis. This material consists of phospate and glycerol. It selectively inhibits in vitro transcription of RNA polymerases, predominantly the homologous enzyme A by binding to the enzyme. In the presence of this inhibitor of transcription a stable RNA polymerase-template complex cannot be formed. Binding to and inactivation of RNA polymerase is reversible at high ionic strength. 
  Reference    Z. Naturforsch. 34c, 76 (1979); received July 3/ November 21 1978 
  Published    1979 
  Keywords    RNA polymerases, Inhibitor, Glycerophosphate, Physarum 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0076.pdf 
 Identifier    ZNC-1979-34c-0076 
 Volume    34