| 1 | Author
| DaivaA. Bironaitė, N. Arim, K. Čėnas, JuozasJ. Kulys, AlexanderG. Medentsev, VasiliyK. Akimenko, P. A. Karplus, E. F. Pai, G. E. Schulz, EurJ. Biochem | Requires cookie* | | Title
|  | | | Abstract
| Fully substituted quinones including som e naturally occurring oxyquinones acted as inhibitors o f yeast gluta thione reductase (EC 1.6.4.2). They were competitive, mixed or uncompetitive inhibitors for N A D P H , possess ing K j in the range o f 1 -2 0 0 |iM and uncompetitive in hibitors for glutathione. Rhein (4,5-dioxy-9,10-anthra-quinone-2-carbonic acid) and 9,10-phenanthrenequi-none were the most effective inhibitors. It is concluded that certain quinones can bind to the N A D P(H)-binding site and to the heteroaromatics binding site at the inter face domain (o f the enzyme. | | |
Reference
| Z. Naturforsch. 46c, 966—9 (1991); received March 4/M ay 71991. 178 6 9 3 -7 0 3 1989 | | |
Published
| 1991 | | |
Keywords
| Glutathione Reductase, Inhibition, Quinones | | |
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| ZNC-1991-46c-0966_n | | | Volume
| 46 | |
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