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1980 (1)
1977 (1)
1Author    Qamar Khalid, M.Ataur RahmanRequires cookie*
 Title    Studies on Synergism between Glucose and Amino Acids with Respect to Insulin Release in vitro  
 Abstract    The mutual enhancement of the effect of insulin release by glucose and amino acids is not clearly understood. Present in vitro studies with isolated rat islets were undertaken to elaborate the role of amino acids on insulin release, particularly their interaction with glucose as well as among each other, which has been reported to lead to synergism in the hum an subjects. In the presence of 8.3 mM glucose, both arginine, as well as, leucine potentiated the effect of glucose which increased progressively with the increasing concentrations of the amino acid. This effect of arginine was not synergistic in nature because arginine did not stimulate insulin release in the absence of glucose. The effect of glucose and leucine was found to be additive and not synergistic. No synergism was exhibited by any o f the am ino acid pairs tested in the present study. Thus both phenylalanine and lysine did not potentiate the effect o f either arginine or leucine. Arginine showed a mild, but significant potentiating effect on leucine-stimulated insulin release. It is suggested that synergism between glucose and amino acids and between certain am ino acid pairs reported in m an may not be due to the direct effects of these stimuli on the beta cells, but some other factors in vivo may be involved. 
  Reference    Z. Naturforsch. 35c, 72—7 (1980); received September 3 1979 
  Published    1980 
  Keywords    Insulin Release, Glucose, Amino Acids, Synergism, Rat Islets 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-0072.pdf 
 Identifier    ZNC-1980-35c-0072 
 Volume    35 
2Author    Requires cookie*
 Title    Yields of 2-Deoxy-D-gluconic, D-Gluconic and Other Sugar Acids in Gamma-Irradiated Aqueous Solutions of D-Glucose  
 Abstract    H e r m a n n E s t e r b a u e r , J a c k S c h u b e r t , E d w a r d B. S a n d e r s , a n d Ch a r l e s C. S w e e l e y The yields of 2-deoxy-D-gluconic, D-gluconic and other sugar acids from 6 0 Co-gamma irradiated (dose rate = 4 Krads/min) D-glucose solutions are reported. The acids produced upon radiolyses were separated from glucose and neutral products by anion exchange, assayed by gas chromatography of the trim ethylsilyl derivatives, and definitive identification made by mass spectrometry. In He degassed, irradiated 0.055 M glucose G(2-deoxy-D-gluconic acid) = 0.62 and G(D-gluconic acid) = 0.20. The approximate G values for the other identified acids are: glyceric acid 0.03, 2-deoxy-tetronic acid 0.04, tetronic acid 0.03, 4-deoxypentonic acid 0.02, deoxyketogluconic acid 0.17. In N 20 saturated glucose solutions D-gluconic acid yields increased by a factor of ~ 1.9 while that of 2-deoxy-D-gluconic acid increased by a factor of only ~ 1.1. 
  Reference    (Z. Naturforsch. 32b, 315—320 [1977]; received October 29 1976) 
  Published    1977 
  Keywords    Irradiation, Glucose, Sugar Acids, 2-Deoxy-D-Gluconic Acid, D-Gluconic Acid 
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 TEI-XML for    default:Reihe_B/32/ZNB-1977-32b-0315.pdf 
 Identifier    ZNB-1977-32b-0315 
 Volume    32