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1999 (1)
1Author    O-Yu Kwona, Yong-Jin Kima, Yongmun Choia, Ho Kimb, Cheol Songc, Minho ShongbRequires cookie*
 Title    The Endoplasmic Reticulum Chaperone G RP94 Is Induced in the Thyrocytes by Cadmium  
 Abstract    We established a relationship between the toxic effects of cadmium on the expression of the endoplasmic reticulum (E R) chaperone GRP94 (glucose regulated protein 94) and cell survival in cultured rat-thyrocytes of FRTL5 cells. There are no data reporting that the en­ hanced expression of G RP94 by Cd stimulation is detectable in thyrocytes. Western blot analysis revealed higher levels of GRP94 expression in those cells post-treated with low concentrations of Cd, following a step-down treatment method, than in Cd pre-treated cells or cells not treated with any Cd, due to changes in cellular sensitivity after pre-treatment with Cd and the possible induction of G RP94 expression after removal of a low concentration of Cd. Elevated G R P94 expression in thyrocytes post-treated with Cd confers a survival advantage by rendering them resistant to cytotoxic stress, and the existence in the thyrocytes of a Cd-specific pathway regulates the expression of stress proteins by Cd. 
  Reference    Z. Naturforsch. 54c, 573—5 (1999); received February 10/May 4 1999 
  Published    1999 
  Keywords    Cadmium, GRP94, Thyrocytes (FRTL5 Cells) 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0573.pdf 
 Identifier    ZNC-1999-54c-0573 
 Volume    54