| | 1 | Author
| H. Erm, Ann Krähling | Requires cookie* | | | Title
| Discrimination of Two Fusogenic Properties of Aqueous Polyethylene Glycol Solutions  | | | | Abstract
| Investigations on the dose response of cell fusion, induced by ionfree aqueous polyethylene glycol (PEG) solutions, reveal distinct lowest fusogenic PEG concentrations for different permanently growing mammalian cell lines. Part o f the requisite PEG can be replaced by carbo hydrates, preserving the fusogenity o f the solutions. This discriminates two effects o f PEG solutions causing cell fusion: a) cell shrinkage, the required hyperosmolality o f the solutions may be provided by PEG or by carbohydrates, is supposed to cause intracellular processes necessary for consolidating polycaryons; b) membrane alterations, which can not be induced by carbo hydrates, enable intimate cell-cell contact via particle-free membrane areas. Depending on cell line salts can not only raise the osmolality o f PEG solutions but are able to co-operate with PEG in generating membrane alterations. | | | |
Reference
| Z. Naturforsch. 36c, 593—596 (1981); received March 111981 | | | |
Published
| 1981 | | | |
Keywords
| Cell Fusion, Polyethylene Glycol, Fusogenic Properties, Carbohydrates, Salts | | | |
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| default:Reihe_C/36/ZNC-1981-36c-0593.pdf | | | | Identifier
| ZNC-1981-36c-0593 | | | | Volume
| 36 | |
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