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1981 (1)
1Author    H. Erm, Ann KrählingRequires cookie*
 Title    Discrimination of Two Fusogenic Properties of Aqueous Polyethylene Glycol Solutions  
 Abstract    Investigations on the dose response of cell fusion, induced by ionfree aqueous polyethylene glycol (PEG) solutions, reveal distinct lowest fusogenic PEG concentrations for different permanently growing mammalian cell lines. Part o f the requisite PEG can be replaced by carbo­ hydrates, preserving the fusogenity o f the solutions. This discriminates two effects o f PEG solutions causing cell fusion: a) cell shrinkage, the required hyperosmolality o f the solutions may be provided by PEG or by carbohydrates, is supposed to cause intracellular processes necessary for consolidating polycaryons; b) membrane alterations, which can not be induced by carbo­ hydrates, enable intimate cell-cell contact via particle-free membrane areas. Depending on cell line salts can not only raise the osmolality o f PEG solutions but are able to co-operate with PEG in generating membrane alterations. 
  Reference    Z. Naturforsch. 36c, 593—596 (1981); received March 111981 
  Published    1981 
  Keywords    Cell Fusion, Polyethylene Glycol, Fusogenic Properties, Carbohydrates, Salts 
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 TEI-XML for    default:Reihe_C/36/ZNC-1981-36c-0593.pdf 
 Identifier    ZNC-1981-36c-0593 
 Volume    36