| 2 | Author
| Daniela Vedaldi, Sergio Caffieri, Giorgia Miolo, Francesco Dall 'acqua, Paola Arslan | Requires cookie* | | Title
| Dark and Photohemolysis of Erythrocytes by Furocoumarins  | | | Abstract
| It has been shown that various furocoumarins are able to cause dark hemolysis in red blood cells (RBC). However, this effect is evident only at relatively high furocoumarin concentrations (4.6 x 10~ 4 M) -much higher than those used in photosensitization experiments or photo-chemotherapeutic treatments. Among the various furocoumarins examined in this study, only psoralen (Ps) and 3-carbethoxy-psoralen (3-CPs) showed strong photohemolytic effects, while the other compounds revealed little or no activity. This fact indicates that Ps and 3-CPs are able to induce selective damage to the cell membrane of RBC. By pre-irradiating furocoumarin in ethanol or isotonic saline solutions and adding the irradiated solutions to a RBC suspension, hemolysis was observed in various compounds. The products of photolysis which form during pre-irradiation may be responsible, in terms of hemolysis, for toxic effects on RBC. | | |
Reference
| Z. Naturforsch. 43c, 888—892 (1988); received August 2 1988 | | |
Published
| 1988 | | |
Keywords
| Furocoumarins, Hemolysis, Photosensitization, Cell Membrane Damage, Photochemotherapy | | |
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| default:Reihe_C/43/ZNC-1988-43c-0888.pdf | | | Identifier
| ZNC-1988-43c-0888 | | | Volume
| 43 | |
3 | Author
| L. Ucia, B. Ovalini, Paola Lusini, Sandra Sim, D. An, Ie La, V. Edaldi, LucioA. Ndreassi, F. Rancesco, D. All, '. A. Cqua, PaolaM. Artelli | Requires cookie* | | Title
| Inhibition of cAMP Phosphodiesterase by Some Phototherapeutic Agents  | | | Abstract
| The behaviour of cyclic-3',5'-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) (usu ally used in PUVA therapy), 4.6,4'-trimethylangelicin (TM A) and khellin recently proposed for the same thera peutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration. | | |
Reference
| Z. Naturforsch. 42c, 1009—1010 (1987); received February 4 1987 | | |
Published
| 1987 | | |
Keywords
| Cyclic AMP Phosphodiesterase, Furocoumarins, Furo-chromones, PUVA Therapy, Psoriasis | | |
Similar Items
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| | | | TEI-XML for
| default:Reihe_C/42/ZNC-1987-42c-1009_n.pdf | | | Identifier
| ZNC-1987-42c-1009_n | | | Volume
| 42 | |
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