| | 1 | Author
| Daniela Vedaldi, Sergio Caffieri, Giorgia Miolo, Francesco Dall 'acqua, Paola Arslan | Requires cookie* | | | Title
| Dark and Photohemolysis of Erythrocytes by Furocoumarins  | | | | Abstract
| It has been shown that various furocoumarins are able to cause dark hemolysis in red blood cells (RBC). However, this effect is evident only at relatively high furocoumarin concentrations (4.6 x 10~ 4 M) -much higher than those used in photosensitization experiments or photo-chemotherapeutic treatments. Among the various furocoumarins examined in this study, only psoralen (Ps) and 3-carbethoxy-psoralen (3-CPs) showed strong photohemolytic effects, while the other compounds revealed little or no activity. This fact indicates that Ps and 3-CPs are able to induce selective damage to the cell membrane of RBC. By pre-irradiating furocoumarin in ethanol or isotonic saline solutions and adding the irradiated solutions to a RBC suspension, hemolysis was observed in various compounds. The products of photolysis which form during pre-irradiation may be responsible, in terms of hemolysis, for toxic effects on RBC. | | | |
Reference
| Z. Naturforsch. 43c, 888—892 (1988); received August 2 1988 | | | |
Published
| 1988 | | | |
Keywords
| Furocoumarins, Hemolysis, Photosensitization, Cell Membrane Damage, Photochemotherapy | | | |
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| default:Reihe_C/43/ZNC-1988-43c-0888.pdf | | | | Identifier
| ZNC-1988-43c-0888 | | | | Volume
| 43 | |
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