| | 1 | Author
| M. Tofazzal Islam3, Satoshi Tahara3b | Requires cookie* | | | Title
| Repellent Activity of Estrogenic Compounds toward Zoospores of the Phytopathogenic Fungus Aphanomyces cochlioides  | | | | Abstract
| Screening chemical compounds, we found that a xenoestrogen, bisphenol A , showed potent repellent activity against the zoospores of A phanom yces cochlioides. Based on this finding, we tested a number of androgenic and estrogenic compounds (e.g. testosterone, progesterone, estradiols, diethylstilbestrol, estrone, estriol, pregnenolone, dienestrol etc.) on the motility behavior of A. cochlioides zoospores. Interestingly, most of the estrogenic compounds exhib ited potent repellent activity (1 ng/ml or less by the "particle m ethod") toward the motile zoospores of A. cochlioides. We derivatized som e of the estrogens and discussed the relation ship between the structure of active m olecules and their repellent activity. Apparently, aro-matization of the A ring with a free hydroxyl group at C-3 position o f a steroidal structure is necessary for higher repellent activity Interestingly, methylation of diethylstilbestrol (D E S) yielded completely different activity i.e. both m ono-and di-methyl ethers o f D ES showed attractant activity. Moreover, the attracted zoospores were encysted and then germinated in the presence of di-methyl ether of DES. The potential usefulness o f this repellent test is discussed for the detection of estrogenic activity o f naturally occurring compounds, and the possible role of phytoestrogens in host/parasite interactions. So far, this will be the first report of repellent activity of estrogenic compounds toward trivial fungal zoospores. | | | |
Reference
| Z. Naturforsch. 56c, 253—261 (2001); received Novem ber 13/Decem ber 18 2000 | | | |
Published
| 2001 | | | |
Keywords
| Repellent Activity, Steroidal Hormones, Fungal Zoospore | | | |
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| default:Reihe_C/56/ZNC-2001-56c-0253.pdf | | | | Identifier
| ZNC-2001-56c-0253 | | | | Volume
| 56 | |
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