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1997 (1)
1996 (1)
1Author    Prof Dr, ErnstRequires cookie*
 Title    Zur Festphasenpeptidsynthese des Makrophagen-migrationsinhibierenden Faktors der Maus (mMIF): Ein Vergleich verschiedener Syntheseansätze zur Darstellung der schwierigen C-terminalen Sequenz mMIF(93-115)  
 Abstract    Solid Phase Peptide Synthetic A ppro ach es to M ouse M acrophage M igration Inhibitory Factor (m M IF): C om parison of D ifferent Strategies Producing the C-Terminal D ifficult Sequence P eptide m M IF (9 3 -1 1 5) Thom as Kaiser, W olfgang V oelter* From solid phase peptide synthetic approaches of mMIF(93-115) the C-terminal sequence turned out to be a typical "difficult sequence" peptide. Various stepwise syntheses were performed with different resins and coupling reagents. The Peptide was synthesized in 90% yield by solid phase fragment condensation of protected mMIF(93-108) to mMIF(109-115) '2-Chlorotrityl' resin bound. 
  Reference    Z. Naturforsch. 52b, 281—295 (1997); eingegangen am 4. Dezember 1996 MIF 
  Published    1997 
  Keywords    Solid Phase Peptide Synthesis, Difficult Sequence, Fragment Condensation, Coupling Conditions 
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 TEI-XML for    default:Reihe_B/52/ZNB-1997-52b-0281.pdf 
 Identifier    ZNB-1997-52b-0281 
 Volume    52 
2Author    B. Ernd, H. Enkel, L.Ianshan Zhang, C. Arsten, G. Oldam, M. Er, E.Rnst BayerRequires cookie*
 Title    Combined Solid Phase and Solution Synthesis of the Fully Protected Segment 74-99 of HIV 1-Protease with the Application of a New Trityl-Linker  
 Abstract    A new trityl-linker for the strategy of combined solid phase and solution synthesis has been used for the synthesis of the fully protected segment 74-99 of HIV 1-protease. The fully protected fragments 74-81, 82-99 and 90-99 have been synthesized on the polystyrene-polyethylenglykol resin TentaGel, split off with dilute acetic acid and assembled in solution without loss of side-chain protecting groups. After protection of the C-terminus of the frag­ ment 90-99, the second fragment was coupled with TBTU/NMM. The couplings were moni­ tored by IS-MS and HPLC. Racemization was checked by chiral gas-chromatography on a Chirasil-Val capillary. 
  Reference    Z. Naturforsch. 51b, 1339—1346 (1996); received April 10 1996 
  Published    1996 
  Keywords    HIV 1-Protease, Trityl-Linker, Fragment Condensation, Peptide Synthesis, Ionspray-MS, Chiral Gas-chromatography 
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 TEI-XML for    default:Reihe_B/51/ZNB-1996-51b-1339.pdf 
 Identifier    ZNB-1996-51b-1339 
 Volume    51