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2000 (1)
1998 (1)
1Author    Halina Kleszczyńska3, Janusz Sarapuk3, MałgorzataO. Święcimskab, StanisławW. ItekbRequires cookie*
 Title    Antioxidative Activity of Some Quaternary Ammonium Salts Incorporated into Erythrocyte Membranes  
 Abstract    The antioxidative activity of two series of amphiphilic compounds from a group of qu ater­ nary ammonium salts has been investigated. They were so-called bifunctional surfactants synthesized to be used as common pesticides or as antioxidants. The latter application was to be ensured by providing the compounds studied with an antioxidant group. Studies on antioxidative possibilities of those compounds were performed on pig erythrocytes. D ue to their hydrophobic parts, they anchor in the erythrocyte membrane and influence the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation. It was found that compounds of both series decreased the oxidation of the membrane lipids. The inhibition of this oxidation increased with the length of their hydrophobic chains up to fourteen carbon atoms. The compounds of the longest hydrophobic chains showed a somewhat weaker antiox­ idative activity. O f the two series studied compounds were more effective having bromide ions as counterions. The corresponding compounds of a second series (chlorides) protected erythrocyte significantly weaker against oxidation. The effect of the compounds on fluidity of the erythrocyte membrane has been studied in order to explain the oxidation results. Change in fluidity of the erythrocyte ghost membranes was found also dependent on length of the hydrophobic part of the compounds and was more pronounced in the case of bro­ mide surfactants. The final conclusion is that the compounds studied can be succesfully used as antioxidant agents of good efficacy. 
  Reference    Z. Naturforsch. 55c, 976—980 (2000); received June 20/August 3 2000 
  Published    2000 
  Keywords    Erythrocyte Membrane, Antioxidant Activity, Fluidity 
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 TEI-XML for    default:Reihe_C/55/ZNC-2000-55c-0976.pdf 
 Identifier    ZNC-2000-55c-0976 
 Volume    55 
2Author    H. Kleszczyńska3, J. Ł. Uczyńskib, S. Witekb, S. PrzestalskiaRequires cookie*
 Title    Hemolytic Activity of Aminoethyl-dodecanoates  
 Abstract    The effect of new lysosomotropic compounds on red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In earlier studies it was shown that the compounds inhibit the growth of yeast and plasma membrane H+-ATPase activity. The study was per­ formed with eight aminoethyl esters of lauric acid variously substituted at nitrogen atom. Esters of dodecanoic acid were chosen for study because at that chain length dimethylamino-ethyl esters showed maximum activity. The hemolytic activity of the substances studied exhib­ its diversified activity in their interaction with the erythrocyte membrane: they differ in hemolytic activity and affect membrane fluidity differently. Erythrocyte membrane fluidity changes under the effect of those compounds which possess highest hemolytic activity. The hemolytic activity of the aminoesters investigated was found to follow a sequence that de­ pended on basicity (i.e. ability of the protonated form formation) of the compound and its polar head group size. The most active are the compounds that possess not more than four carbon atoms substituted at nitrogen and highest pKa value. 
  Reference    Z. Naturforsch. 53c, 101 (1998); received November 3/December 1 1997 
  Published    1998 
  Keywords    Lysosomotropic Substances, Aminoesters of Fatty Acids, Erythrocyte Membrane, Hemolytic Activity, Fluidity 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0101.pdf 
 Identifier    ZNC-1998-53c-0101 
 Volume    53