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'Erythrocytes' in keywords Facet   Publication Year 1980  [X]
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1980[X]
1Author    Ping-Lu LiRequires cookie*
 Title    Cytotoxicity of Cobra (Naja naja kaouthia) Venom on Rabbit Red Blood Cells and S-180 Tumor Cells in the Presence of Tetracaine, Lidocaine and Procaine  
 Abstract    The cytocidal action of Naja naja kaouthia venom on rabbit red blood cells and S-180 tumor cells treated with local anesthetics (tetracaine, lidocaine and procaine) were studied. The S-180 cells were more sensitive to the venom than the red blood cells which required albumin for ef­ ficient hemolysis in the 10 minute assay. All three local anesthetics at lower concentrations protected both cell types against venom hemolysis. At higher concentrations the local anesthetics enhanced the cell lysis to 100%. The effectiveness of the local anesthetics for both the inhibition and enhancement phases of cytotoxicity was tetracaine > lidocaine > procaine. This is the same order as their anesthetic effectiveness, lipid solubility and their protein binding. 
  Reference    Z. Naturforsch. 35c, 268 (1980); received October 8 1979 
  Published    1980 
  Keywords    Local Anesthetics, Cobra Venom, Cytotoxicity, Erythrocytes, Tumor Cells 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-0268.pdf 
 Identifier    ZNC-1980-35c-0268 
 Volume    35 
2Author    Peter Scheurich, Ulrich Zimmermann, Maja Mischel, Ingolf LamprechtRequires cookie*
 Title    Membrane Fusion and Deformation of Red Blood Cells by Electric Fields  
 Abstract    Human red blood cells suspended in a slightly hypotonic solution o f low electric conductivity were exposed to an inhomogeneous and alternating electric field (sine wave, 30 V peak-to-peak value, electrode distance 120 |im, 0.5 to 2 MHz). Due to the dielectrophoretic effect the cells align parallel to the field lines under the formation o f pearl chains. At high voltages (10 V amplitude) membrane fusion is observed between the adhered red blood cells in the pearl chains, whereby the chains become attached to the electrodes. In contrast to the pearl chains observed at voltages o f up to 5 V amplitude the resulting fused and uniform aggregates which exhibit no recognisable individual cells under the light microscope, remain stable, even after the alternating electric field has been switched off or after haemolysis in response to osmotic shock. The fused aggregates are highly elastic. If the field strength o f the applied alternating electric field is further increased they are stretched in the direction o f the opposite electrode. Frequently, bridges are formed between the two electrodes. The uniform bridges remain stable for some time even in the absence o f an electric field. The possibility o f cell fusion and its initiation by electrical breakdown of the cell membranes are discussed. 
  Reference    Z. Naturforsch. 35c, 1081—1085 (1980); received August 21 1980 
  Published    1980 
  Keywords    Deformability, Dielectrophoresis, Electric Breakdown, Erythrocytes, Fusion 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-1081.pdf 
 Identifier    ZNC-1980-35c-1081 
 Volume    35