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1979 (1)
1Author    J. Freise, P. Magerstedt, F. W. SchmidtRequires cookie*
 Title    Die in vitro und in vivo Stabilität des Einschlusses von Methotrexat in negativ geladenen Liposomen nach Sterilfiltration The in vitro and in vivo Stability of the Entrapment of Methotrexate in Negatively Charged Liposomes after Sterile Filtration  
 Abstract    The preparation of sterile artificial liposomes (phosphatidylcholine: cholesterol: dicethylphos-phate = 5 : 5 : l) by Millipore® filtration is described. Conditions for storing liposome entrapped Methotrexate have been found which allow storage of the drug in the entrapped form over a period of at least 4 months. It is shown that intravenously injected liposome entrapped Metho­ trexate is retained for at least 15 hours in the particulate form. During this time no free Metho­ trexate is detectable in the blood. 
  Reference    Z. Naturforsch. 34c, 114 (1979); eingegangen am 16. August/10. November 1978 
  Published    1979 
  Keywords    Methotrexate, Liposomes, Endocytosis, Cell Membrane 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0114.pdf 
 Identifier    ZNC-1979-34c-0114 
 Volume    34