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'Electron Microscopy' in keywords Facet   Publication Year 1978  [X]
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1978[X]
1Author    H. Wesch, R. Jonak, H. Nemetschek-Gansler, H. Riedl, Th NemetschekRequires cookie*
 Title    Der Einfluß von D-Penicillamin auf den Gehalt einiger Organe an Spurenelementen sowie auf die mechanischen Eigenschaften von Kollagen Trace Elements in Several Organs and Mechanical Properties of Collagen under the Influence of D-Penicillamin  
 Abstract    The content of trace elements in several organs of rats under the influence of D-penicillamine (D-PA) was investigated by the neutronactivation-analysis. It could be shown an diminution of Cu, and Co under D-PA-treatment, the content of Fe, Mn, Rb and Zn was not influenced. The investigat­ ed organs didn't show any submicroscopic alterations under D-PA. On isolated collagen fibrils of tail tendon was seen a significantly diminuition of E-moduls. In accordance with Siegel the principal effect of D-PA is thought to block the synthesis of functional groups from Schiff-base crosslink precursors but not to inhibit lysyloxidase by loss of Cu-ions of connective tissue. The thermostability of D-PA influenced fibrils is changed in stretched state only and will be due to the lack of crosslink Schiff-bases; where as the shrinking point of not stretched fibrils shows only aging dependent changes. 
  Reference    Z. Naturforsch. 33c, 346 (1978); eingegangen am 17. März 1978 
  Published    1978 
  Keywords    D-Penicillamin, Trace Elements, Electron Microscopy, Biosynthesis, Cross-Links, Mechanical Properties of Collagen 
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 TEI-XML for    default:Reihe_C/33/ZNC-1978-33c-0346.pdf 
 Identifier    ZNC-1978-33c-0346 
 Volume    33