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1985 (1)
1979 (1)
1Author    Petra Köpf-Maier, Hartmut KöpfRequires cookie*
 Title    Vanadocen-dichlorid - ein weiteres Antitumor-Agens aus der Metallocenreihe Vanadocene Dichloride -Another Antitumor Agent from the Metallocene Series  
 Abstract    The antitumor activity of vanadocene dichloride is investigated against Ehrlich ascites tumor in CFi mice. The application of 80 or 90 mg/kg 24 h after transplantation achieves 100% tumor inhibition until day 30. On treatment with higher doses death of an increasing number of animals is caused by substance toxicity. The results of this study indicate that vanadocene dichloride exhibits antineoplastic properties similar to those found for titanocene dichloride and cis-dichlorodiammine-platinum(II). 
  Reference    Z. Naturforsch. 34b, 805—807 (1979); eingegangen am 15. März 1979 
  Published    1979 
  Keywords    Vanadocene Dichloride, Metallocenes, Antitumor Activity, Ehrlich Ascites Tumor 
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 TEI-XML for    default:Reihe_B/34/ZNB-1979-34b-0805.pdf 
 Identifier    ZNB-1979-34b-0805 
 Volume    34 
2Author    Petra Köpf-MaierRequires cookie*
 Title    Tumor Inhibition by Ferricenium Complexes: Systemic Effect in vivo and Cell Growth Inhibition in vitro  
 Abstract    The antiproliferative activity of divers ferricenium complexes [CpiFe]+X " (X -= [CCl3COO]~ • CCI3COOH (I); X ' = [CCl,COO] • 2 CCI3COOH (II); X " "= l A [Cl3FeOFeCl3]2-(III); X^ = [FeCl4]~ (IV); X = [2 ,4.6-(N02)3Q H 2 0 ] (V)) was investigated against solid, subcutane-ously growing Ehrlich ascites tumor (EAT) in vivo as well as against EAT cells cultivated in vitro as permanent suspension culture. In vivo, triple intraperitoneal injections of the complexes II (3 x 200 mg/kg), III (3 x 100, 140, 180 mg/kg) or IV (3 x 160 mg/kg) markedly suppressed tumor development thus that the sizes of treated tumors were reduced to 42—48% related to control tumors (100%); these results point to the systemic character of the antitumor action by ferri­ cenium complexes in vivo. In vitro, all ferricenium complexes inhibited cellular proliferation to an equal extent; application of 10-5 m diminished the increase in cell number by 20—40%, applica­ tion of 10-4 m resulted in a total cessation of cellular proliferation. In comparison to cw-diam-minedichloroplatinum(II), the cell growth-inhibiting effect of ferricenium complexes was less pronounced and required 10-to 50-fold higher concentration levels to evoke equivalent cytostasis. 
  Reference    Z. Naturforsch. 40c, 843 (1985); received August 1 1985 
  Published    1985 
  Keywords    Ferricenium Complexes, Ehrlich Ascites Tumor, Systemic Effect in vivo, Cell Growth Inhibition in vitro 
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 DEBUG INFO      
 TEI-XML for    default:Reihe_C/40/ZNC-1985-40c-0843.pdf 
 Identifier    ZNC-1985-40c-0843 
 Volume    40