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1995 (1)
1994 (1)
1Author    Kirsten Lorenzen, Timm Anke, Uwe Anders, H. Erm An Hindermayr, Fritz HansskeRequires cookie*
 Title    Two Inhibitors of Platelet Aggregation from a Panus Species (Basidiomycetes)  
 Abstract    Two inhibitors of platelet aggregation were isolated from fermentations of Panus sp. 9096. One inhibitor proved to be identical to naematolon (2), an antibiotic previously isolated by S. Backens et al. from several Hypholoma species. The other metabolite, panudial (1), is a new nordrimane (cw-annelation of the bicyclus) lacking the carbon atom in position 10 of the drimane skeleton. Panudial is a potent inhibitor of bovine and human platelet aggregation stimulated by different inducers. 
  Reference    Z. Naturforsch. 49c, 132—138 (1994); received September 1/ 
  Published    1994 
  Keywords    Basidiomycetes, Lentineae, Panus Species, Platelet Aggregation, Antibiotics, Drimanes 
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 TEI-XML for    default:Reihe_C/49/ZNC-1994-49c-0132.pdf 
 Identifier    ZNC-1994-49c-0132 
 Volume    49 
2Author    Z. NaturforschRequires cookie*
 Title    Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)  
 Abstract    G erh ard E rk e l3, K irsten L o ren zen 3, Timm A n k ea, R obert V eltenb, A lb erto G im en ezb, and W olfgang Steglichb In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Kj 200 ^i m) and moloney murine leukemia virus (K; 40 (.i m) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities. 
  Reference    Z. Naturforsch. 50c, 1 (1995); received October 5 1994 
  Published    1995 
  Keywords    Kuehneromyces sp, Basidiomycetes, Sesquiterpenoids, Drimanes, Nordrimanes 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0001.pdf 
 Identifier    ZNC-1995-50c-0001 
 Volume    50